Registration Dossier
Registration Dossier
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EC number: 229-114-0 | CAS number: 6413-10-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- other: study report summary
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- No guideline, or experimental methodology, stipulated in report summary.
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP
- Test type:
- other: no data
- Limit test:
- yes
Test material
- Reference substance name:
- Fructone
- IUPAC Name:
- Fructone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No further information on test animals and environmental conditions is reported.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- 5.0 g/kg
- No. of animals per sex per dose:
- 10 animals were used in the study.
- Control animals:
- not specified
- Details on study design:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 other: g/kg
- Based on:
- not specified
- Mortality:
- None of the 10 animals tested died during the study.
- Clinical signs:
- other: Toxic signs at 5.0 g/kg included lethargy, ataxia, ptosis, diarrhea, piloerection, chromorhinorrhea and chromodacryorrhea.
- Gross pathology:
- Nine of the survivors appeared normal at necropsy. One animal had dark areas in the lungs and a yellow exudate in the nose/mouth.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 of the test material was reported to be in excess of 5.0 g/kg.
- Executive summary:
The acute oral toxicity of the test material was investigated with 10 rats in a limit test. The animals were orally administered test material at 5.0 g/kg.
None of the 10 animals tested died during the study. Toxic signs at 5.0 g/kg included lethargy, ataxia, ptosis, diarrhea, piloerection, chromorhinorrhea and chromodacryorrhea. At necropsy, nine of the animals appeared normal. One animal had dark areas in the lungs and a yellow exudate in the nose/mouth.
The acute oral LD50 of the test material was reported to be in excess of 5.0 g/kg.
The summary report contains extremely limited detail on experimental conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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