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Diss Factsheets
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EC number: 619-682-1 | CAS number: 224049-04-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
One study is available investigating the short-term toxicity of Isotianil to soil macroorganisms (OECD 207). The study was conducted with Eisenia fetida. Since no mortality occurred the study resulted in a LC50 (14d) > 1000 mg/kg soil dw.
Furthermore two studies investigating the toxicity of the test item to soil microorganisms are available. Effects on the activity of soil microflora were investigated in a carbon transformation test by Schulz (2012a). This study was conducted in compliance with GLP and according to the OECD test guideline 217. Microorganisms were exposed for 28 days to 0.80 and 8.00 mg test item/kg soil dry weight. No adverse effects of Isotianil on carbon transformation in soil were observed at either test concentration.
In a second study the effects on the activity of soil microflora were investigated in a nitrogen transformation test by Schulz (2012b). This study was also conducted in compliance with GLP and followed the OECD test guideline 216. Microorganisms were exposed for 70 days to 0.80 and 8.00 mg test item/kg soil dry weight. The test item Isotianil caused a temporary stimulation of the daily nitrate rate at the tested concentration of 0.80 mg/kg dry soil at time interval 7-14 days after application. However, no adverse effects of Isotianil on nitrogen transformation in soil could be observed at the tested concentration of 0.80 mg/kg dry soil, 28 days after application (time interval 14-28 days). Temporary stimulations of the daily nitrate rate were also observed at 8.00 mg/kg dry soil beginning at time interval 7-14 until time interval 42-56 days after application. However, no adverse effects of Isotianil on nitrogen transformation in soil could be observed at the tested concentration of 8.00 mg/kg dry at the end of the test, 70 days after application (time interval 56-70 days).
In conclusion, Isotianil tested in a field soil at concentrations up to 8.00 mg test item/kg soil (equivalent up to an application rate of 6 kg test item/ha) caused no adverse effects (difference to control < 25%) on the soil nitrogen transformation at the end of the 70-day incubation period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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