α,α,α,β,β,β-hexafluoro-m-xylene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

October 27 - November 17, 1999

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Report date:

1994

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OTS 798.1175 (Acute Oral Toxicity)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

α,α,α,β,β,β-hexafluoro-m-xylene

EC Number:

206-939-4

EC Name:

α,α,α,β,β,β-hexafluoro-m-xylene

Cas Number:

402-31-3

Molecular formula:

C8H4F6

IUPAC Name:

1,3-bis(trifluoromethyl)benzene

Test material form:

other: liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: oleum maydis germinis

Doses:

oleum maydis germinis

No. of animals per sex per dose:

5 male and 5 female rats

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths occurred during the study period.

Clinical signs:

No clinical signs of toxicity were observed during the observation period.

Body weight:

The body weight was not affected during the observation period.

Other findings:

The macroscopic examination of the animals at terminal necropsy revealed no organ abnormalities.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The mean lethal dose of meta-hexa-fluoro xylene after single oral administration to rats of both sexes, observed over a period of 14 days, could not be estimated, because no deaths occurred at the maximal dose of 2000 mg test article/kg body weight.