α,α,α,β,β,β-hexafluoro-m-xylene

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

August 05 - 26, 1998

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

GLP compliance:

yes

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

α,α,α,β,β,β-hexafluoro-m-xylene

EC Number:

206-939-4

EC Name:

α,α,α,β,β,β-hexafluoro-m-xylene

Cas Number:

402-31-3

Molecular formula:

C8H4F6

IUPAC Name:

1,3-bis(trifluoromethyl)benzene

Test material form:

other: liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

corn oil

Duration of exposure:

14 days

Doses:

The test article was diluted in vehicle (corn oil) at a concentration of 0.5 g/mL and administered at a volume of 4 ml/kg.

No. of animals per sex per dose:

5 male and 5 female rats

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

No deaths occurred during the study.

Crusts were observed on the application site in one male animal from test day 7 to 12. No clinical signs were observed in all other male and female animals during the observation period. Two female animals showed a slight loss of body weight during the first week of observation. They recovered during the second week of observation. The body weight of all other animals was within the range comonly recorded for animals of this strain and age.

No macroscopic findings were observed at necropsy.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The median lethal dose of 1,3 Hexafluoroxylene after single dermal administration to rats of both sexes, observed over a period of 14 days, could not be estimated as no death occurred. LD50 is greater than 2000 mg/kg body weight.