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EC number: 222-376-7 | CAS number: 3452-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
3,5,5-trimethylhexan-1-ol was irritating in an OECD TG 404 test conducted under GLP and using rabbits.
3,5,5-trimethylhexan-1-ol was slightly irritating to the rabbit's eye in an OECD TG 405, GLP study using rabbits, below the EU classification criteria.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL per animal
- Concentration (if solution): undiluted
VEHICLE
- Amount(s) applied (volume or weight with unit): n.a. - Duration of treatment / exposure:
- 4 hours
- Observation period:
- min. 7 days
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: no data
- % coverage: no data
- Type of wrap if used: semiocclusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize method - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24-72 hours
- Score:
- 2.08
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1.83
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: desquamation on day 7 in all 6 animals
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.22
- Reversibility:
- not fully reversible within: 7 days
- Irritant / corrosive response data:
- The test substance caused well-defined erythema in two of the six animals and mild erythema in the remaining animals at the 45 minute interval.
At 24, 48, and 72 hours, 5 animals had well-defined erythema and 1 animal had mild erythema. By Day 7, only one animal had slight erythema.
One animal at the 48 hour interval and 3 animals at the 72 hour interval had slight edema.
By Day 7, desquamation was observed in all 6 animals. - Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 3, 5, 5-trimethylhexan-1-ol was irritating to the rabbit's skin, as desquamation was seen in all animals on day 7, i.e. possibly at the end of the observation period
- Executive summary:
3, 5, 5-trimethylhexan-1-ol was moderately irritating in an OECD TG 404 test conducted under GLP and using 6 female rabbits. Following a 4 hour contact of the neat test material to the intact skin under semiocclusive dressing, the mean erythema score for 24, 48, and 72 hours after patch removal was 1.83 (mean edema score: 0.22). Erythema was reversible, but desquamation was seen in all 6 animals on day 7 after patch removal (EBSI, 1992; only secondary source available).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- No eye wash
- Observation period (in vivo):
- 10 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no
- Time after start of exposure:
SCORING SYSTEM: Draize method; readings at approx. 1, 24, 48, and 72 hours, and on days 7 an d10
TOOL USED TO ASSESS SCORE: no data - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- mean score of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0.2
- Max. score:
- 0.7
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- mean score of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 0.3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- mean score of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0.8
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Conclusions:
- 3,5,5-trimethylhexan-1-ol was slightly irritating to the rabbit's eye below the level of the EU criteria for labelling
- Executive summary:
3, 5, 5-trimethylhexan-1-ol was slightly irritating to the rabbit's eye when it was tested according to OECD TG 405 under GLP in 3 rabbits. The maximum Draize score reached was 18 out of 110. The corneal and conjunctival effects were all fully reversible within 7 days.
In conclusion, 3, 5, 5-trimethylhexan-1-ol was only slightly irritating to the rabbit's eye below the level of the EU criteria for labelling (EBSI, 2002).
Reference
Effect |
Mean scores (3 animals) |
|||||
1 h |
24 h |
48 h |
72 h |
7d |
10 d |
|
Corneal opacity |
0 |
0 |
0 |
0.7 |
0 |
0 |
Conjunctival chemosis |
1.0 |
0.3 |
0.3 |
0.3 |
0 |
0 |
Conjunctival redness |
1.0 |
1.0 |
0.7 |
0.7 |
0 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin: 3, 5, 5-trimethylhexan-1-ol was moderately irritating in an OECD TG 404 test conducted under GLP and using 6 female rabbits. Following a 4 hour contact of the neat test material to the intact skin under semiocculsive dressing, the mean erythema score for 24, 48, and 72 hours after patch removal was 1.83 (mean edema score: 0.22). Erythema was reversible, but desquamation was seen in all 6 animals on day 7 after patch removal (EBSI, 1992; only secondary source available).
Eye: 3, 5, 5-trimethylhexan-1-ol was slightly irritating to the rabbit's eye when it was tested according to OECD TG 405 under GLP in 3 rabbits. The maximum Draize score reached was 18 out of 110. The corneal and conjunctival effects were all fully reversible within 7 days. In conclusion, 3, 5, 5-trimethylhexan-1-ol was slightly irritating to the rabbit's eye below the level of the EU criteria for classification and labeling (EBSI, 2002; only secondary source available).
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
Skin:
the mean erythema score was 1.83 on three consecutive days; desquamation persisted until the end of the observation period.
Regulation 67/548/EEC: classification criteria not met
Regulation 1272/2007/EC: irritating; Cat 2; H315
Eye:
Regulation 67/548/EEC: classification criteria not met
Regulation 1272/2007/EC: irritating, cat.2; H319
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