Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-trimethylbenzoyl chloride
EC Number:
213-339-6
EC Name:
2,4,6-trimethylbenzoyl chloride
Cas Number:
938-18-1
Molecular formula:
C10H11ClO
IUPAC Name:
2,4,6-trimethylbenzoyl chloride
Details on test material:
- Name of test material (as cited in study report): 2.4.6-Trimethylbenzoylchlorid
- Physical state: liquid
- Analytical purity: no data
- Expiration date of the lot/batch: October 1981

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gaukler, Offenbach/Main
- Age at study initiation: no data
- Weight at study initiation: 2.37 - 3.23kg
- Housing: single in steel mesh cages (40x51cm)
- Diet (e.g. ad libitum): SSNIFF standard diet for rabbits (4mm) and Ovator Solikanin (4mm) app. 130g/day and animal
- Water (e.g. ad libitum): app. 250ml per day and animal
- Acclimation period: app. 8 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26°C
- Humidity (%): 50-80%
- Photoperiod (hrs dark / hrs light): 12h/12h

Test system

Type of coverage:
occlusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of same animal
Amount / concentration applied:
app. 0.5ml
Duration of treatment / exposure:
3min, 1h, 4h
Observation period:
8 days, observations after 15-30min, 24h, 48h, and 8 days
Number of animals:
8 (3min: 4 females; 1h: 2 females; 4h: 1male, 1female)
Details on study design:
TEST SITE
- Area of exposure: 2.5 X 2.5cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol and Lutrol/water (1:1)
- Time after start of exposure: after end of exposure, i.e., 3min, 1h, or 4h after start of exposure

SCORING SYSTEM: according to Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
other: both animals
Time point:
other: 24h
Score:
2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 4h exposure, necrosis, animals killed after 24h
Irritation parameter:
erythema score
Basis:
other: both animals
Time point:
other: 24h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 4h exposure, necrosis, animals killed after 24h
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24h, 48h, 8 days
Score:
1.7
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1h exposure, necrosis in both animals
Irritation parameter:
erythema score
Basis:
other: both animals
Time point:
other: 24h, 48h , 8days
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 1h exposure, necrosis
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24h, 48h (mean)
Score:
3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 3min exposure, necrotic spots
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24h, 48h (mean)
Score:
2.5
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 3min exposure, necrotic spots
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24h, 48h (mean)
Score:
2.5
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 3min exposure, necrosis
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24h, 48h (mean)
Score:
2.5
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 3min exposure (necrosis)
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24h, 48h (mean)
Score:
2
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: 3min exposure, severe scale formation
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 24h, 48h (mean)
Score:
1
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: 3min exposure, severe scale formation
Irritation parameter:
erythema score
Basis:
animal #4
Time point:
other: 24h, 48h (mean)
Score:
1.5
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: 3min exposure, severe scale formation
Irritation parameter:
edema score
Basis:
animal #4
Time point:
other: 24h, 48h (mean)
Score:
0.5
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: 3min exposure, severe scale formation

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Conclusions:
After 3min occlusive exposure with the test substance, necrosis was observed after 24h in 2 of 4 rabbits, while all rabbits showed necrotic lesions after longer exposure times. Thus, the substance is corrosive to the rabbit skin.