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EC number: 429-790-9 | CAS number: 137281-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 November 1998 to 16 December 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid
- EC Number:
- 429-790-9
- EC Name:
- 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid
- Cas Number:
- 137281-39-1
- Molecular formula:
- Hill formula: C15 H14 N4 O3 CAS formula: C15 H14 N4 O3
- IUPAC Name:
- 4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)benzoic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Compound 202723
- Storage condition of test material: In the dark at ambient temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: outside vendor
- Age at study initiation: 6 -8 weeks old
- Weight at study initiation: 149-186 grams
- Fasting period before study: Overnight prior to dosing
- Housing: Polypropylene cages with stainless steel grid tops and bottoms
- Diet: ad libitum supply of 'Rat and Mouse No. 1 Maintenance Diet' animal feed
- Water: ad libitum supply of domestic mains water
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature : 19 -20 °C
- Humidity: 39 -54%
- Air changes (per hr): minimum of 15
- Photoperiod (hrs dark / hrs light): 12 hr light/dark cycle (light hours 07:00-19:00)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled
- Details on oral exposure:
- An appropriate quantity of test material was added to the requisite amount of distilled water and mixed manually until visibly homogeneous. Test material was administered orally in a single dose by means of a gavage at a constant dose volume of 10ml/kg. Administered dose was calculated based on the weight of the animal on the day of dosing.
- Doses:
- Dose ranging treatment levels:
500 mg/kg
2000 mg/kg
Based on the results of the dose ranging, the main study was conducted at a dose level of 2000 mg/
kg. - No. of animals per sex per dose:
- Preliminary sighting study: 0 (male)
Preliminary sighting study: 2 (female)
Main study: 5 (male)
Main study: 5 (female) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Daily
- Frequency of body weight measurements: Dose ranging study - day of dosing (Day 1) only & Main s tudy - day of dosing (Day1), Day 2, 3,4, 8 and 15
- Necropsy of survivors performed: yes, on main study animals only - examination of the thoracic and abdominal organs and tissues in situ.
- Clinical observations: All animals were examined for reaction to treatment. The onset, intensity and duration of any signs were recorded. - Statistics:
- No formal statistical analysis was conducted
Results and discussion
- Preliminary study:
- No adverse clinical signs were noted in the preliminary sigthting study conducted at fixed dose levels of 500mg/kg and 2000 mg/kg in female animals.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred
- Clinical signs:
- There were no adverse clinical signs noted during the observation period.
- Body weight:
- Body weight performance was unaffected by treatment
- Gross pathology:
- Effects on organs:
None - Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 rat > 2000 mg/kg
- Executive summary:
This study investigated the acute oral toxicity of compound 202723 after a single oral gavage administration to Sprague-Dawley rats.
Following preliminary dose ranging, at 500 and 2000 mg/kg, 5 male and 5 female rats, included in the main study, received 2000mg/kg. The test material was administrered using distilled water as a vehicle, at a dose volume of 10ml/kg. The animals were observed daily for viability and signs of reaction to treatment for up to 14 days after dosing. Body weights were recorded on Days 1,2,3,4,8 and 15. A necropsy examination was performed after death on all main study animals.
There were no premature decedents or adverse clinical signs during the study. Body weight performance was unaffected by treatment and no abnormalities were noted at necropsy.
Under the conditions of the study, following a single oral administration of intermediate 202723 to Sprague-Dawley rats, no mortality and no toxicity occurred at 2000mg/kg.
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