Registration Dossier
Registration Dossier
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EC number: 404-170-0 | CAS number: 70750-63-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The toxicokinetic assessment was derived from available physiochemical and toxicity data, not based on actual experimental examinations..
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Toxicokinetic assessment was performed based on physicochemical properties and available toxicity data
- GLP compliance:
- not specified
Test material
- Details on test material:
- - Physical state: blue powder
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Strain:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- Not Applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not Applicable
- No. of animals per sex per dose / concentration:
- Not Applicable
- Control animals:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Not applicable
- Details on dosing and sampling:
- Not applicable
- Statistics:
- Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
Results and discussion
- Preliminary studies:
- Not Applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not Applicable
- Details on distribution in tissues:
- Not Applicable
Transfer into organs
- Transfer type:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Observation:
- not determined
- Details on excretion:
- Not Applicable
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Not Applicable
Any other information on results incl. tables
The information used for toxicokinetic assessment was listed below:
Physicochemical Property And Toxicity Test Data Of 1779u
Property |
Value |
Molecular Formula |
(C32H15CuN8).(O3S)x(C38H80N)x, x= 1.2~1.4 |
Physical |
Blue powder |
Particle Size |
46.6% passed through a 38mm sieve |
Melting Point |
> 250oC |
Specific Gravity |
1.26 g/cm3 |
Water Solubility |
< 0.24 mg/L |
Acute Oral Toxicity, Rat |
> 5000 mg/kg |
Acute Dermal Toxicity, Rat |
> 2000 mg/kg |
Skin Irritation, Rabbit |
Not classified |
Eye Irritation, Rabbit |
Not classified |
Skin Sensitization, Guinea-pig |
Not classified |
Sub-acute Toxicity, Rat |
NOEL 1000 mg/kg/day |
Inhibition of Activated Sludge Respiration |
LC50 > 1000 mg/L |
Algal Toxicity |
NOEC > 0.24 mg/L |
There was evidence of systemic toxicity in the repeat dose toxicity study at 1000 mg/kg/day, with effects seen in the spleen, stomach and liver indicating that absorption, possible metabolism and excretion process were involved.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: predicted no bioaccumulation.
Based on the representative chemical structure and available physicochemical property and toxicity data, a prediction of toxicokinetic behavior was created, and absorption, distribution to distance organs, possible metabolism and excretion process were involved. - Executive summary:
The test material has a molecular weight range from 1332.4 (x=1.2) to 1458.6 (x=1.4). It is poorly water soluble (< 0.24 mg/L). Based on the representative chemical structure and available physicochemical property and toxicity data, a prediction of toxicokinetic behavior was created
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