Registration Dossier
Registration Dossier
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EC number: 404-170-0 | CAS number: 70750-63-9
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 21 - March 24, 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to guideline under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
- GLP compliance:
- yes
Test material
Constituent 1
Results and discussion
Solubility in organic solvents / fat solubility
- Medium:
- standard fat
- Solubility:
- 0.047 other: mg/kg
- Temp.:
- 37 °C
- Test substance stable:
- not determined
- Details on results:
- - For data see Table [1].
Any other information on results incl. tables
The results of the individual measurements of the main study are summarized in Table 1:
Table 1. Solubility (mg/kg) in Standard Fat HB307 at 37 C
Shaking time (hours) |
Group 1 (undersaturation) |
Group 2 (oversaturation) |
3 |
0.0455 |
0.0463 |
3 |
0.0415 |
0.0457 |
24 |
0.0489 |
0.0485 |
24 |
0.0494 |
0.0480 |
Applicant's summary and conclusion
- Conclusions:
- The solubility of the test material in standard fat HB307, as determined by OECD 116, is 0.0467 mg/kg at 37 degrees C.
- Executive summary:
Following OECD 116, the solubility of the test material in a standard fat was measured. The standard fat, HB 307, used for the study was a synthetic mixture of saturated triglycerides with a fatty acid and triglyceride distribution similar to that found in coconut fat..
Following stirring times of 3 hours and 24 hours at 37 C, the concentration of the test material solubilized in the fat was measured by UV-Vis spectrophotometry. No significant differences were observed in the fat solubility with different equilibration/stirring times.
The mean fat solubility was determined to be 0.0467 mg/kg standard fat.
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