Registration Dossier
Registration Dossier
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EC number: 470-710-7 | CAS number: 139122-17-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Micronucleus test)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test animals
- Species:
- other: Mouse(albino)
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- Arachis oil B.P.
- No. of animals per sex per dose:
- Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 72 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice times: 72 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Results and discussion
Test results
- Toxicity:
- yes
- Remarks:
- Doses producing toxicity: 5000 mg/kg
- Additional information on results:
- Observations:
There was no evidence of a biologically significant increase
in the incidence of micronucleated polychromatic or
normochromatic erythrocytes in animals dosed with the test
material when compared to the vehicle control groups. No
significant changes in the NCE/PCE ratio was observed after
dosing with the test material.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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