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EC number: 234-028-1 | CAS number: 10497-05-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Tris(trimethylsilyl) phosphate
- EC Number:
- 234-028-1
- EC Name:
- Tris(trimethylsilyl) phosphate
- Cas Number:
- 10497-05-9
- Molecular formula:
- C9H27O4PSi3
- IUPAC Name:
- tritrimethylsilyl phosphate
Constituent 1
- Specific details on test material used for the study:
- Test Item Tris(trimethylsilyl) Phosphate
Lot Number DV1105A19028
CAS No 10497-05-9
EINECS-No 234-028-1
Molecular Formula C9H27O4PSi3
Molecular Weight 314.54
Purity 99.60%
Appearance Colorless, clear liquid
Composition Single component
Homogeneity Not stated
Storage Room temperature (20 ± 5 °C)
Test Item Handling and Storage According to SOPA-00147-BIO, Test and Reference Items
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Age at First Dose 8-9 weeks; female animals were non-pregnant and nulliparous
Animal Health Health condition of animals was examined by a veterinarian before initiation of the study.
Acclimation The animals were acclimated under the conditions identical to the conditions during the experiment 5 days prior to the start of treatment. The acclimation was according to the standard operation procedure.
Housing Condition The animals were housed in plastic cages suspended on stainless steel racks, 3 animals per cage in a room equipped with central air-conditioning. The average room temperature was maintained within the range of 22 ± 3°C, relative humidity within 50-60 %. The light regimen was set to a 12-hour light /12-hour dark cycle. The sanitation was performed according to the standard operation procedures.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- The starting dose could be selected from the fixed dose levels of 5, 50, 300, and 2000 mg/kg body weight.
- No. of animals per sex per dose:
- One group of 3 females was dosed in a first step. The test item in limit dose caused mortality of two animals within the first day after administration and the third animal died on the second day. In a second step, 3 females were treated at dose of 300 mg/kg body weight. Test item-related mortality was not observed for 48 hours and therefore, in a third step, another 3 females were treated at the same dose cap
- Details on study design:
- The test item Tris(trimethylsilyl) Phosphate administered to 3 females Wistar rats at a limit dose of 2000 mg/kg caused lethargy, dyspnea in all animals immediately after administration and piloerection after 4 hours in animal No 3. Animals No 1 and 2 died within the first day after test item administration. Animal No 3 manifested lethargy, dyspnea and piloerection until the death the second day after administration. During necropsy, no macroscopic findings were observed.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Mortality:
- Mortality of 3/3 females at limit dose of 2000 mg/kg body weight was observed.
All (6/6 females) animals survived the dose of 300 mg/kg body weight. - Other findings:
- All animals were necropsied. During necropsy, no macroscopic findings were observed.
Any other information on results incl. tables
Clinical observation
Sex |
Dose |
ID |
Administration Result |
Clinical Observation |
♀ |
2000 mg/kg |
1 |
death |
- lethargy and dyspnea immediately, persisted for 4 hours - piloerection after 4 hours after administration - death the first day after administration of the test item |
2 |
death |
- lethargy and dyspnea immediately, persisted for 4 hours - piloerection after 4 hours after administration - death the first day after administration of the test item |
||
3 |
death |
- lethargy and dyspnea immediately persisted for 4 hours - piloerection after 4 hours after administration; - first day lethargy, piloerection and dyspnea occurred - second day lethargy, piloerection and dyspnea occurred until death of animal (on second day) |
Sex |
Dose |
ID |
Administration Result |
Clinical Observation |
♀ |
300 mg/kg |
4 |
alive |
no signs of intoxication, change of health, nor any other adverse reactions during 24 hours and 14-days observation period |
5 |
alive |
no signs of intoxication, change of health, nor any other adverse reactions during 24 hours and 14-days observation period |
||
6 |
alive |
- salivation, lethargy and piloerection was observed immediately - lethargy persisted for ½ an hour - piloerection was observed until 2ndhour after administration |
||
7 |
alive |
- lethargy was observed immediately and persisted for ½ an hour - sleep was observed ½ an hour after administration |
||
8 |
alive |
- lethargy was observed immediately |
||
9 |
alive |
- lethargy was observed immediately |
Body Weight
Sex |
Dose |
ID |
Body Weight (g) |
Body Weight Difference (g) |
||||
Initial |
Week 1 |
Week 2 |
Week 1 - Initial |
Week 2 - Initial |
Week 2 - Week 1 |
|||
♀ |
2000 mg/kg |
1 |
213 |
- |
- |
- |
- |
- |
2 |
201 |
- |
- |
- |
- |
- |
||
3 |
206 |
- |
- |
- |
- |
- |
||
♀ |
300 mg/kg |
4 |
216 |
246 |
252 |
30 |
36 |
6 |
5 |
216 |
246 |
261 |
30 |
45 |
15 |
||
6 |
226 |
245 |
251 |
19 |
25 |
6 |
||
7 |
216 |
233 |
238 |
17 |
22 |
5 |
||
8 |
224 |
245 |
258 |
21 |
34 |
13 |
||
9 |
213 |
236 |
238 |
23 |
25 |
2 |
Necropsy Results
Sex |
Dose |
ID |
Result |
♀ |
2000 mg/kg |
1 |
autolytic changes |
2 |
autolytic changes |
||
3 |
no findings |
||
300 mg/kg |
4 |
no findings |
|
5 |
no findings |
||
6 |
no findings |
||
7 |
no findings |
||
8 |
no findings |
||
9 |
no findings |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 of the test item Tris(trimethylsilyl) Phosphate is greater than 300 mg/kg and lower than 2000 mg/kg body weight after single oral administration to Wistar rats.
Based on Annex 2d Test Procedure with a Starting Dose of 2000 mg/kg body weight of OECD Guideline 423 it can be concluded that the test item Tris(trimethylsilyl) Phosphate is classified in GHS Category 4 with a LD50 cut off value 500 mg/kg body weight, after single oral administration to Wistar rats.
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