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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2020-06-15 - 2020-06-19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
485 mg/L
Conc. based on:
act. ingr.
Temp.:
20 °C
pH:
4.095

The study was performed based on OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The validity criteria were fulfilled:

Validity Criteria and Results

 

Validity Criterion

Required

This study

Repeatability

The concentration measured in at least the samples with the two longest incubation times (48 and 72 h) should not differ by more than 15%.

7.3%
(for 24, 48 and 72 h)

Temperatures

pre-incubation temperature: 30 ± 0.5 °C

30.03 ±0.02 °C

test temperature: 20 ± 0.5 °C

19.96 ±0.02 °C

 

Conclusions:
The water solubility of Quaternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined to be 485 mg/L (20 °C, pH 4.095).
Executive summary:

The water solubility of Quaternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre‑incubation at 30 ± 0.5 °C.

 The analytical method (LC‑MS/MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.

The water solubility of Quaternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined to be 485 mg/L (20 °C, pH 4.095)

Description of key information

485 mg/L at 20°C (flask method)

Key value for chemical safety assessment

Water solubility:
485 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of Quaternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre‑incubation at 30 ± 0.5 °C.

 The analytical method (LC‑MS/MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.

The water solubility of Quaternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfateswas determined to be 485 mg/L (20 °C, pH 4.095)