Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 850-698-3 | CAS number: 2387913-24-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019-08-21 to 2019-09-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- 30 May 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 13 April 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 3.1
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not specified
- Conclusions:
- The n-octanol/water partition coefficient (log Kow) of Quarternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline no. 117 [adopted on 13 April 2004] and EU test method A.8 [Council Regulation (EC) No 440/2008 of 30 May 2008] with the HPLC method. The weighted average log Kow was 3.1 at 25.0 °C ± 0.2 °C.
- Executive summary:
The n-octanol/water partition coefficient (log Kow) of Quarternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline no. 117 [adopted on 13 April 2004] and EU test method A.8 [Council Regulation (EC) No 440/2008 of 30 May 2008] with the HPLC method.
Summary of the results of the HPLC measurements of the reference compounds and the test item:
Sample
no.1)
tR1
[min]
tR2
[min]
tR
[min]
k’
log k’(x)
log POW(y)
0
1.190
1.199
1.195
---
---
---
1
1.895
1.899
1.897
0.587
-0.231
3.42)
2
1.950
1.955
1.953
0.634
-0.198
2.72)
3
2.189
2.196
2.193
0.835
-0.078
3.22)
4
2.564
2.568
2.566
1.147
0.060
4.52)
5
3.016
3.016
3.016
1.524
0.183
4.62)
6
4.318
4.323
4.321
2.616
0.418
6.52)
7
10.295
10.300
10.298
7.618
0.882
7.92)
Test item peaks
tR
[min]
k’
log k’(x)
log POW(y)3)
log POWmean value (rounded)
Weighted average
log Pow
1
1.763
0.475
-0.323
2.483
2.5
3.1
1.764
0.476
-0.322
2.488
2
2.038
0.705
-0.152
3.283
3.3
2.038
0.705
-0.152
3.283
3
2.318
0.940
-0.027
3.867
3.9
2.318
0.940
-0.027
3.867
4
2.822
1.362
0.134
4.620
4.6
2.830
1.368
0.136
4.630
5
6.134
4.133
0.616
6.874
6.9
6.146
4.143
0.617
6.879
1) For the names of the reference compounds see 9.3.
2) Results from the OECD guideline for the testing of chemicals No. 117: „Partition Coefficient (n-octanol/water), HPLC method“ (13 April 2004).
3) Interpolated from linearized function log POW= f(log k’ ) of the calibration data.
The test item was determined by double determination in two independent measurements.
The deviation of the single log POW-values of the test item from the mean value fall within a range of
≤0.1 units as given by the guideline.
Reference
Description of key information
The n-octanol/water partition coefficient (log Kow) of Quarternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline no. 117 [adopted on 13 April 2004] and EU test method A.8 [Council Regulation (EC) No 440/2008 of 30 May 2008] with the HPLC method. The weighted average log Kow was 3.1 at 25.0 °C ± 0.2 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.1
- at the temperature of:
- 25 °C
Additional information
The n-octanol/water partition coefficient (log Kow) of Quarternary ammonium compounds, tri-C8-C10-alkylmethyl, Me sulfates was determined according to OECD guideline no. 117 [adopted on 13 April 2004] and EU test method A.8 [Council Regulation (EC) No 440/2008 of 30 May 2008] with the HPLC method. The weighted average log Kow was 3.1 at 25.0 °C ± 0.2 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
