Registration Dossier
Registration Dossier
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EC number: 701-350-3 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18th March 2019 to 7th June 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- According to the test design, a phase separation via centrifugation was not necessary. This deviation was considered to have no impact on quality and integrity of the study
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Test material is a UVCB
- Key result
- Water solubility:
- 398 µg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 6
- Conclusions:
- The water solubility of the test item was determined to be 398 μg/L (20°C, pH 6)
- Executive summary:
Water solubility for the test substance was determined in accordance with OECD guideline 105. The solubility for the test item, in purified water (18.2 MQ/cm), was determined employing the flask method with slow stirring approach at 20+/-0.5deg with incubation at test temperature for 72h before the first sampling. The analytical method (LC-MS/MS, external standard) was validated and tested with satisfactory results in regards to linearity, accuracy , precision and specificity.
The water solubility of the test item was determined to be 398 μg/L (20°C, pH 6)
Reference
Water Solubility Results at 20 °C
1) Incubation Time = Time after application
2) Calculated concentration = Exact weight of the external standard taken into account
| Incubation Time [h] | Calculated Concentration [µg/L] Replicate 1 |
Calculated Concentration [µg/L] Replicate 1 |
|
| 408.65 | 443 | 366 | |
| 410.73 | 408 | 360 | |
| 428.93 | 407 | 374 | |
| 430.93 | 424 | 374 | |
| 433.57 | 415 | 403 | Overall |
| Mean | 419 | 376 | 398 |
| Deviation [%] | 8.9 | 11.9 | 11.7 |
Description of key information
Key value for chemical safety assessment
- Water solubility:
- 398 µg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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