Registration Dossier
Registration Dossier
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EC number: 615-927-1 | CAS number: 7319-16-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 8.11. - 12.12.1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study performed according to OECD and GLP guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (E)-1-methoxyprop-1-ene
- EC Number:
- 615-927-1
- Cas Number:
- 7319-16-6
- Molecular formula:
- C4H8O
- IUPAC Name:
- (E)-1-methoxyprop-1-ene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 7 days
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1 hour to 7 days
- Score:
- ca. 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1 hour to 7 days
- Score:
- ca. 0.4
- Reversibility:
- fully reversible within: 72 hours
- Other effects:
- -
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Not irritating
- Executive summary:
After single 4h occlusive application Propenylmethylether induced very slight slowly disappearing skin reactions on intact rabbit skin. According to the calculated primary irritation score of 1.0 can be classified as non-irritating for rabbit skin. Based on the results of this study it can be assumed that short-lasting exposure of limited human skin areas to Propenylmethylether will not be connected with risk for the health of man
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