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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed according to OECD and GLP guidelines
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
(E)-1-methoxyprop-1-ene
EC Number:
615-927-1
Cas Number:
7319-16-6
Molecular formula:
C4H8O
IUPAC Name:
(E)-1-methoxyprop-1-ene

Test animals

Species:
rat
Strain:
other: Fu-Albino outbred stock Ibm:RORO
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
arachis oil
Doses:
0 and 2000 mg/kg
No. of animals per sex per dose:
5 per sex per dose
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD 50 is > 2000 mg/kg bw
Executive summary:

Assessed with this method Propenylmethylether has a very low order of toxicity (approx. LD50 p.o. rat > 2000mg/kg body weight). All animals showed control behaviour during the whole 14-day observation period. All animals showed weight gain within normal limits. No signs of gross pathological changes were found by necropsy at the end of the observation period.