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Diss Factsheets
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EC number: 251-073-2 | CAS number: 32509-66-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Dec 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study design equivalent to OECD Guideline 401 with minor deviation and sufficient reporting.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- only females tested
- GLP compliance:
- no
- Remarks:
- performed before GLP guidelines
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- DTB-Glycolester
- IUPAC Name:
- DTB-Glycolester
- Reference substance name:
- Bis[3.3-bis(4'-hydroxy-3-tertiarybutylphenyl)-butanoic acid]-glycolester
- IUPAC Name:
- Bis[3.3-bis(4'-hydroxy-3-tertiarybutylphenyl)-butanoic acid]-glycolester
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- white powder
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst bred
- Weight at study initiation: 90 - 104 g
- Fasting period before study: 16 h before administration
- Housing: in plastic cages on a bedding of wood shavings
- Diet (e.g. ad libitum): Altromin 1324 (Atlrogge, Lage/Lippe, Germany), ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- - concentration in vehicle: 25 % (w/v)
- Doses:
- 15000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
No food was given to he rats for 16 h before administration. Food was given to the animals again 2 h after administration of the product. The period of observation after administration amounted to 14 days. During this period the animals were weighed weekly.
At the end of the subsequent observation period the animals were sacrificed and subjected to macroscopic evaluation. - Statistics:
- None
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 15 000 mg/kg bw
- Remarks on result:
- other: no effects
- Mortality:
- no mortality observed
- Clinical signs:
- other: The behavior of the animals was normal both after administration and during the subsequent follow-up period.
- Gross pathology:
- Dissection of the sacrificed animals yielded no significant macroscopic findings.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose of Hostanox O 3 (LD50) was greater than 15000 mg per kg body weight. Based on the result of this study Hostanox O 3 is not subject for labelling and classification requirements according to regulatory requirements.
- Executive summary:
Hostanox O 3 was tested for its acute oral toxicity potential. 10 female rats were treated with 15000 mg/kg bw and observed for 14 days. No deaths or clinical signs were recorded.
The median lethal dose of Hostanox O 3 (LD50) was greater than 15000 mg per kg body weight. Based on the result of this study Hostanox O 3 is not subject for labelling and classification requirements according to regulatory requirements.
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