Registration Dossier
Registration Dossier
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EC number: 253-391-7 | CAS number: 37203-76-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
Since phosphoric acid, ethyl ester is a corrosive substance (pH in aqueous systems is 0.2-1.0) strong cytotoxicity is to be expected causing irreversible destruction of any marker cell system even at low concentrations. Therefore, to avoid marker cell destruction due to corrosivity, the concentration to be tested would have to be extremely low. As a consequence any results from these extremely low concentrations would not adequately represent realistic human exposure situations and therefore would not be indicative to assess any potential genotoxicity under realistic conditions.
According to REACH Annex XI (2) testing may be omitted if it is technically not possible to perform the test. Phosphoric acid, ethylester is a corrosive substance with a pH of 0.3. Therefore strong cytotoxicity is to be expected at exposure conditions relevant for humans.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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