Registration Dossier
Registration Dossier
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EC number: 253-391-7 | CAS number: 37203-76-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethyl dihydrogen phosphate
- EC Number:
- 216-603-9
- EC Name:
- Ethyl dihydrogen phosphate
- Cas Number:
- 1623-14-9
- Molecular formula:
- C2H7O4P
- IUPAC Name:
- Phosphoric acid,monoethyl ester
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Mono and Diethyl ester of phosphoric acid
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 5 times/week
- Number of animals:
- 10
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Basis:
- mean
- Time point:
- 7 d
- Reversibility:
- not reversible
- Remarks on result:
- probability of severe irritation
- Irritant / corrosive response data:
- severe necrosis
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive) based on GHS criteria
- Conclusions:
- Phosphoric acid, ethylester was found to be corrosive to rabbits skin.
- Executive summary:
Phosphoric acid, ethylester was found to be corrosive to rabbits skin.
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