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Diss Factsheets
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EC number: 203-894-2 | CAS number: 111-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as not assignable because the study is not GLP compliant and concentrations tested are not provided.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Study was performed prior to adoption of the test guideline specified.
- Principles of method if other than guideline:
- The study was conducted according to the Federal Hazardous Substance Labelling Act (FHSLA).
- GLP compliance:
- no
- Test type:
- other: acute vapour inhalation screening
- Limit test:
- no
Test material
- Reference substance name:
- Dec-1-ene
- EC Number:
- 212-819-2
- EC Name:
- Dec-1-ene
- Cas Number:
- 872-05-9
- Molecular formula:
- C10H20
- IUPAC Name:
- dec-1-ene
- Details on test material:
- - Name of test material (as cited in study report): Decene-1
- Substance type: C10 alpha olefin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: Air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Glass cylinder chamber
- Exposure chamber volume: Approximately 20 litres
- Source and rate of air: Source not provided; air introduced at a rate of 2 L/min
TEST ATMOSPHERE
- Brief description of analytical method used: Test material concentrations were calculated based on bubbler weight loss and amount of air passed through the bubbler.
VEHICLE
- Composition of vehicle (if applicable): Air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Theoretical chamber concentrations were calculated on the basis of bubbler weight loss and amount of air passed through the bubbler.
- Duration of exposure:
- ca. 1 h
- Concentrations:
- Not provided
- No. of animals per sex per dose:
- Dosing range not provided; 10 male rats were exposed to 1-decene
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animas were observed periodically, but detailed Information not provided
- Necropsy of survivors performed: yes
- Other examinations performed: Necropsied animals were examined for gross pathology; specific details on gross pathology not provided
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: An LC50 was not calcuated
- Remarks on result:
- other: Exposed rats exhibited sleepy, slightly dazed appearance 45 minutes post-exposure. Recovery was observed immediately after exposure. Autopsy revealed no gross pathological changes. No mortalities or significant weight changes were observed post exposure.
- Gross pathology:
- .
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- An acute LC50 was not reported based on the study conducted. Criteria used for interpretation of results: EU
- Conclusions:
- The author did not provide any conclusive statements with regards to the potential toxicity of 1-decene. An acute LC50 was not reported based on the study conducted.
- Executive summary:
In an acute vapour inhalation screening study, rats were exposed to saturated vapours of 1-decene for 1 hour. Exposed rats showed minimal effects characterized by sleepy, slightly dazed appearance that began 45 minutes post-exposure. Recovery was observed to be immediate upon removal from the exposure chamber. Autopsy conducted at the end of the 14-day observation period revealed no gross pathological changes. In addition, no mortalities or significant weight changes were observed post exposure. The study author did not provide any information or conclusions regarding the determination of an LC50 for 1-decene.
This study received a Klimisch rating of 4 and is classified as not assignable because the study is not GLP compliant and the concentrations tested are not provided.
This study was selected as a supporting study because it received a lower Klimisch score than the selected read-across studies; however, this study contains relevant and useful data, allowing it to qualify as a supporting study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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