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EC number: 203-894-2 | CAS number: 111-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, acceptable with restrictions
- Justification for type of information:
- Read-across between the target substance Oct-2-ene (EC 203-894-2 / CAS 111-67-1) and source substance 1-Decene (EC 212-819-2/ CAS 872-05-9) is based upon the similarity of the chemical structures and their respective physico-chemical properties. The ECHA Read-Across Assessment Framework (RAAF) states that substances with qualitatively similar properties can form the basis of read-across in circumstances where the source and target substances share such similar characteristics.
Target substance Oct-2-ene and source substance 1-Decene are each mono-constituent linear olefins. Structurally, the differences between source and target substances include: 1) the length of the carbon chain (eight for the target substance, and ten for the source substance); and 2) the location of the carbon-carbon double bond (uniformly at the C2 position for the target substance, but uniformly at the C1 terminal position for the source substance).
The target and source substances both fit within the boundaries of chemical category of higher olefins. Studies conducted by the HOPA consortium on a large range of higher olefin category members (including 1-Decene) demonstrated sufficiently similar physico-chemical, environmental fate and toxicological properties to substantiate the basis for read-across; category members in the C6-C10 range may be moderately toxic to highly toxic to aquatic organisms and environmental toxicity is expected to be manifested as non-polar narcosis. Therefore Oct-2-ene (which falls within the C6-C10 range) is expected to behave similarly. Justification for inclusion of Oct-2-ene within the boundaries of the higher olefins category, and the relevance of each category member as an analogue substance to Oct-2-ene, is provided in Section 13 (Document name: “HOPA Higher Olefins CJD with Category Matrix Report [rev 1 Sept 2016]”; Document name: "ACC Product Stewardship Summary for Higher Olefins Category (2008-12-03)”). - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Test concentrations were renewed daily, and analysis made at on and off. Samples will be taken from midway between top, bottom and sides of the test vessel.
- Vehicle:
- yes
- Details on test solutions:
- A concentrated 10 mg/ml stock solution of dec-1-ene was made by adding 100mg in 10 ml DMF.
The required amount of the stock solution was then added to dechlorinated water and stirred for 48 hours in airtight sealed vessels with the minimum headspace to give a nominal loading of 0.064, 0.14, 0.31, 0.68 and 1.5 mg/l test substance. DWC and solvent control test solutions were also be stirred for 48 hours. - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Fish were held on site for at least 12 days before use and were not used if treated within 7 days of test start or if more than 3% mortality with 48 hours of test start. Not fed for 24 hours prior to or during the test.
- Test type:
- other: daily renewal
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal concentration of 0.064, 0.14, 0.31, 0.68 and 1.5 mg/l test substance. Mean measured concentrations 0.0213, 0.05, 0.1049, 0.191, 0.2523mg/l. Measured concentrations fluctuated outside acceptable limits so results are reported based on nominal loading rates.
- Details on test conditions:
- Test conducted in glass vessels of at least 20 litres working volume to achieve a loading capacity of no more than 1 g of fish per litre of test solution. The test vessels will be sealed to limit any potential losses of the test substance. A photoperiod of 16 hours of light, followed by 8 hours of dark, with dawn and dusk transition periods.
- Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 1.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- no mortality seen in blank or solvent control. One mortality in highest exposure group
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 96 hour LC50 is >1.5mg/l..
- Executive summary:
The toxicity of dec-1 -ene to fish was investigated in an OECD 203 test with Oncorhynchus mykiss (Brixham Environmental Laboratories, 2010). Due to the low solubility of the test substance the test used a solvent carrier. The test substance was mixed with the solvent before being added to the dilution water. It was then stirred for 48 hours under sealed conditions to maximise the exposure concentrations. The test was carried out with sealed test vessels and the solutions were renewed daily to minimise the loss of the test substance. Measured concentrations did not remain above the solubility (0.31mg/l) throughout the exposure period in any of the test concentrations, so results are reported based on nominal loading rates. After 96 hours there were no mortalities in the blank control or solvent control. A single mortality was seen in the highest exposure concentration. These results are interpreted as demonstrating that the 96 hour LC50 of dec-1 -ene is >1.5mg/l nominal.
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 24.07.1995-14.06.1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline, available as an unpublished report, limitations in design but otherwise adequate for assessment
- Justification for type of information:
- Read-across between the target substance Oct-2-ene (EC 203-894-2 / CAS 111-67-1) and source substance Alkenes, C7-9-branched, C8-rich (EC 307-300-3 / CAS 97593-00-5) is based upon the similarity of the chemical structures and their respective physico-chemical properties. The ECHA Read-Across Assessment Framework (RAAF) states that substances with qualitatively similar properties can form the basis of read-across in circumstances where the source and target substances share such similar characteristics.
Target substance Oct-2-ene and source substance Alkenes, C7-9-branched, C8-rich are mono-constituent and UVCB olefins, respectively. Structurally, the differences between source and target substances include: 1) the length of the carbon chain (uniformly eight for the target substance, but variably seven to nine for the source substance); 2) the position of the carbon-carbon double bond (uniformly at the C2 position for the target substance, but variable for the source substance); and 3) the degree of branching (the target substance is a linear, non-branched structure, whereas branching in the source substance is variable).
The target and source substances both fit within the boundaries of chemical category of higher olefins. Studies conducted by the HOPA consortium on a large range of higher olefin category members (including Alkenes, C7-9-branched, C8-rich) demonstrated sufficiently similar physico-chemical, environmental fate and toxicological properties to substantiate the basis for read-across; category members in the C6-C10 range may be moderately toxic to highly toxic to aquatic organisms and environmental toxicity is expected to be manifested as non-polar narcosis. Therefore Oct-2-ene (which falls within the C6-C10 range) is expected to behave similarly. Justification for inclusion of Oct-2-ene within the boundaries of the higher olefins category, and the relevance of each category member as an analogue substance to Oct-2-ene, is provided in Section 13 (Document name: “HOPA Higher Olefins CJD with Category Matrix Report [rev 1 Sept 2016]”; Document name: "ACC Product Stewardship Summary for Higher Olefins Category (2008-12-03)”). - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- no certificate
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data reported - Analytical monitoring:
- yes
- Details on sampling:
- Samples of WAFs taken on Day 0, 1, 2, and 3 and from old WAFs on Day 1 and at termination. Observations of fish performed on all replicate chambers at 3, 24, 48 72 and 96hr. pH, dissolved oxygen and temperature measured on new WAF on Days 0, 1, 2 and 3. Temperature, dissolved oxygen and pH measured on the old WAF on Days 1, 2 and 3 and at termination.
- Vehicle:
- no
- Details on test solutions:
- WAFs prepared by addition of the appropriate amount of TS to 19.5L of laboratory dilution water in a 20L size glass carboy. WAFs siphoned from the bottom of the vessel. Vessels sealed. Renewal treatment and control mixtures prepared daily. New WAF siphoned into the bottom of the bottle.
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Obtained from Thomas Fish Company, Anderson, CA. Held in dilution water for at least 12 days prior to test and at 14±1°C for at least 7 days prior to testing. Fish were fed Salmon Starter, Salmon Crumble and/or Tetramin flake fish food. 72 fish. Age: 6 weeks at test initiation. Mean weigt - 0.272g, mean total length - 3.5cm. (smaller than the length specified in the protocol in order to maintain sufficient dissolved oxygen levels).
- Test type:
- other: semi-static, renewal, no headspace
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- none
- Hardness:
- 174-178 CaCO3 mg/l
- Test temperature:
- mean test temperature = 15°C
- pH:
- 7.0-8.7
- Dissolved oxygen:
- 6.8-10.2 mg/l
- Salinity:
- not applicable
- Nominal and measured concentrations:
- Loading rates: 2.6mg/l, 4.3mg/l, 7.2mg/l, 12mg/l and 20mg/l. A control of lab dilution water also tested. Mean measured concentrations were 0.19, 0.36, 0.70, 1.2 and 2.5mg/l. Practical Quantitation Limit was 0.03mg/l.
- Details on test conditions:
- test chambers were 4L glass aspirator bottles. 4 fish per chamber. 3 replicate chambers per treatment. 16h light 8h dark. 578-580 Lux during full daylight periods for the study. Not fed for at least 24hrs prior to study start or during the study.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.87 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 0.79-0.96
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.36 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- based on the mean of the measured concentrations of the 'new' and 'old' WAFs for each treatment
- Results with reference substance (positive control):
- No data reported
- Reported statistics and error estimates:
- the 24, 48, 72 and 96h LC50 and LL50 values calculated using the Spearman-Karber Method.
- Validity criteria fulfilled:
- yes
- Remarks:
- Validity criteria met
- Conclusions:
- The reported 96h LC50 was 0.87mg/l.
- Executive summary:
The reported 96h LC50 was 0.87mg/l. This study is GLP compliant and follows a standard guideline, with only minor deviations. It is considered reliable and suitable for use for this endpoint.
Referenceopen allclose all
Description of key information
Two key studies were selected based on analog substances. Both key studies were semistatic acute fish toxicity tests on the effects of the analog substances on the freshwater rainbow trout (Oncorhynchus mykiss) following OECD Guideline 203. In the first key study, (Davi RA, 1996), the 96-h NOEC was reported as 0.36 mg/L and the 96-h LC50 was reported as 0.87 mg/L based on measured concentrations. In the second key study, (Brixham Environmental Laboratories, 2010), the 96-h LC50 was reported as > 1.5 mg/L based on nominal concentrations. The key value (96-h LC50 = 0.87 mg/L) was based upon the lower of the two values from the two key studies.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.87 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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