Registration Dossier
Registration Dossier
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EC number: 818-033-1 | CAS number: 1629579-82-3
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Mar 2018 to 03 May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- March 04, 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- January 22, 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC Technical Guidance Document on Risk Assessment Part III Chapter 4.3: Use of (Quantitative) Structure Activity Relationships ((Q)SARs) - Soil and Sediment Sorption.
- Version / remarks:
- 2003
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Specific details on test material used for the study:
- Appearance: Clear to transparent yellow liquid
Purity/Composition: Not indicated
Test item storage: At room temperature - Test temperature:
- 20 °C
- Details on study design: HPLC method:
- Analytical Conditions
Instrument: Acquity UPLC system (Waters, Milford, MA, USA)
Detector: Acquity UPLC PDA detector (Waters)
Detector: Xevo TQ-S mass spectrometer (Waters)
Column: Acquity UPLC HSS Cyano, 100 mm x 2.1 mm i.d., dp = 1.8 µm (Waters)
Column temperature: 35 ± 1°C
Injection volume: 5 µL
Mobile phase: 55/45 (v/v) methanol/buffer pH 4
Flow: 0.4 mL/min
UV detection: 210 nm
MS detection:
- Ionization source: ESI+
- Cone voltage: 40 V
- Quantitation: m/z 221
MS detection
- Ionization source: ESI-
- Cone voltage: 40 V
- Quantitation: m/z 115 - Key result
- Type:
- log Koc
- Value:
- < 1.26 dimensionless
- pH:
- 4
- Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test material has been determined to be log Koc: < 1.26.
- Executive summary:
The adsorption coefficient (Koc) of the test material has been determined in accordance to the standardised guideline OECD 121, under GLP conditions log Koc: < 1.26.
Reference
Description of key information
The adsorption coefficient (Koc) of the test material has been determined in accordance to the standardised guideline OECD 121, under GLP conditions log Koc: < 1.26.
Key value for chemical safety assessment
- Koc at 20 °C:
- 1.26
Additional information
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