Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 245-904-8 | CAS number: 23843-64-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-08-22 to 2003-09-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated non-adapted sludge from the Marl-Ost municipal sewage treatment plant.
- Preparation of inoculum for exposure: inoculum batches were aerated with moist air for three days in the dark.
- Concentration of sludge: 20 ml sludge in 9980 ml mineral medium
- Initial cell/biomass concentration: 108 * 10(4) CFU/ml (colony forming units/ml)
- Water filtered: no - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: See below
- Test temperature: 20.9 - 22.4
- pH: 7.1
- Aeration of dilution water: Aerated over night before addition of inoculum
- Suspended solids concentration: 7.4 mg/l
- Continuous darkness: yes
TEST SYSTEM
- Number of culture flasks/concentration: 2
- Measuring equipment: TOC-5000A; Shimadzu
SAMPLING
- Sampling frequency: days 0, 2, 7, 9, 14, 19, 21, 28
- Sampling method: TIC analysis
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
- Abiotic sterile control: No
- Toxicity control: Yes
STATISTICAL METHODS: Not needed - Reference substance:
- benzoic acid, sodium salt
- Test performance:
- Under the present test conditions, the test substance was biodegraded by an average of 86 % over the 28-day exposure period. The criterion for ready biodegradability (60 % within 10 days) was met.
The reference compound was biodegraded by an average of 93 % at the end of 28 days, confirming the suitability of the sludge inoculum. - Parameter:
- % degradation (CO2 evolution)
- Value:
- 86
- Sampling time:
- 28 d
- Remarks on result:
- other: Batch of tested substance contains 50% methanol
- Details on results:
- See table 1
- Results with reference substance:
- See table 1
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- After 28 days, a mean degradation rate of 86 % was found in the study. However the tested batch of the substance, contains 50% methanol, which would biodegrade rapidly. Furthermore the substance hydrolyses in contact with water to a silanol hydrolysis product and ethanol. The silanol hydrolysis product, 3-Ureidopropylsilanetriol, is not expected to biodegrade to any significant extent. The high degradation rate is attributed to the rapid biodegradability of methanol and ethanol in the test media.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification attached in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 86
- Sampling time:
- 28 d
- Remarks on result:
- other: Batch of tested substance contains 50% methanol
Referenceopen allclose all
Table 1. Percentage biodegradation of test item, of benzoic acid, sodium salt and of the toxicity control
Day |
0 |
2 |
7 |
9 |
14 |
19 |
21 |
28 |
|
% Deg |
D1 |
0.77 |
42.15 |
70.88 |
61.69 |
60.92 |
79.31 |
85.82 |
75.1 |
D2 |
0.38 |
36.4 |
88.12 |
90.8 |
93.87 |
62.84 |
82.67 |
97.7 |
|
mean |
1 |
39 |
80 |
76 |
77 |
71 |
84 |
86 |
|
% Deg |
R1 |
0 |
68.85 |
84.23 |
89.23 |
91.92 |
93.46 |
97.31 |
91.54 |
R2 |
0.77 |
69.23 |
91.15 |
86.15 |
90.77 |
96.54 |
95.38 |
94.23 |
|
mean |
0 |
69 |
88 |
88 |
91 |
95 |
96 |
93 |
D1 – D2 = Dynasylan 2201
R1 – R2 = Benzoic acid, sodium salt
Description of key information
Not readily biodegradable (OECD 310, RA CAS No. 23779 -32 -0)
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
There are no reliable ready biodegradation data available for the registered substance 1-[3 -(trimethoxysilyl)propyl]urea (CAS No. 23843-64-3). Therefore, good quality data from the analogue substance 1-[3-(triethoxysilyl)propyl]urea (CAS No. 23779-32-0) have been read across.
The registered (target) substance hydrolyses within the timescale of a ready biodegradation test to form the silanol hydrolysis product [3-(trihydroxysilyl)propyl]urea and the alcohol hydrolysis product methanol (DT50 = 2.8 h, QSAR). Both the target substance and the analogue substance used as read-across source substance share the same silanol hydrolysis product (i.e. [3-(trihydroxysilyl)propyl]urea), the other hydrolysis products are methanol and ethanol, which are readily biodegradable (OECD, 2004a and OECD, 2004b). Details on the read across justification can be found in IUCLID Section 13.
The biodegradation of the analogue substance 1-[3-(triethoxysilyl)propyl]urea (CAS No. 23779-32-0) was tested according to the OECD guidance 310 and GLP standards (2003). The inoculum - non adapted, activated sludge - was exposed for 28 d to 20 mg/L test substance. The tested batch of the test item contains 50 % methanol, which would biodegrade rapidly. Furthermore, the test substance hydrolyses in contact with water to [3-(trihydroxysilyl)propyl]urea and ethanol. Ethanol is known to biodegrade rapidly as well. After 28 days, a mean degradation rate of 86% was found. However, the ready biodegradation of this substance is mainly attributed to the high fraction of carbon within the alkoxy/acetoxy groups of the molecule, relative to the fraction of carbon within the hydrocarbon group attached to the silicon. The corrected biodegradation once alkoxy/acetoxy biodegradation is accounted for, was calculated to be 26%.
Therefore,the silanol hydrolysis product, [3-(trihydroxysilyl)propyl]urea is not expected to biodegrade to any significant extent. The high degradation rate is attributed to the readily biodegradability of methanol and ethanol in the test media. The biodegradation of the silanol hydrolysis product, once a complete biodegradation of methanol and ethanol has been taken into account can thus be regarded as negligible.
On this basis the substance 1-[3-(trimethoxysilyl)propyl]urea (CAS No. 23843-64-3) is not considered readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.