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EC number: 214-183-1 | CAS number: 1111-67-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Tests commenced on 19 September 1985 and completed on 29 October 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted to internationally recognised guidelines but not to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Deviations:
- yes
- Remarks:
- See notes in section " Principles of method if other than guideline"
- Principles of method if other than guideline:
- The study design differs from current OECD Test Guideline methods for acute oral toxicity (400, 423, 425), however, meets all data needs for hazard classification and labelling in the EU. Review of the study report revealed minor deviations from current scientific and technical standards.
The following minor deviations from current scientific and technical standards were noted:
- Test substance purity was not reported,
- Age of test animals was not reported.
These deviations are not considered to have influenced the outcome or the integrity of the study. - GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- Copper thiocyanate
- EC Number:
- 214-183-1
- EC Name:
- Copper thiocyanate
- Cas Number:
- 1111-67-7
- Molecular formula:
- CHNS.Cu
- IUPAC Name:
- copper thiocyanate
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- A test material in a container labelled Cuprous Thiocyanate CuSCN, Batch No. 8571 (gross weight 554g) was received on 07 August 1985.
Storage conditions: The test material was stored in the dark under ambient conditions.
Purity: Not provided.
Stability: Not provided.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (U.K.) Limited
- Age at study initiation: No information was given on the age of the animals.
- Weight at study initiation: At the start of the study the males weighed 205 to 221 g and the females weighed 148 to 160 g.
- Fasting period before study: Deprived of food for 16-18h before dosing.
- Housing: Rats were housed in suspended plastic cages with mesh floors with a maximum of 5 animals per cage.
- Diet (e.g. ad libitum): Special Diet Services Expanded Rat and Mouse Maintenance Diet No. 1, allowed ad libitum.
- Water (e.g. ad libitum): Available ad libitum.
- Acclimation period: 9 days before test commencement
ENVIRONMENTAL CONDITIONS
- Temperature: Mean environmental temperature was 20°C (extremes of 19°C-22°C)
- Humidity: Mean relative humidity was 55% (extremes of 42 - 66%).
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light):
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 1%
- Details on oral exposure:
- Cuprous Thiocyanate was administered orally in a single dose by means of a gavage. The test material was prepared in 1% carboxymethyl cellulose before administration and each group was dosed at a constant dose volume of 20ml per kg body weight.
- Doses:
- Concentration: 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of clinical observations: The rats were observed frequently on the day of dosing and for 14 days following dosing.
- Weighing: Animals were weighed immediately prior to dosing, 7 days after dosing and at the end of the 14 day observation period.
- Necropsy of survivors performed: Each animal was subjected to a gross post mortem examination. - Statistics:
- Method of determination of LD50: Not applicable, limit dose study.
Results and discussion
- Preliminary study:
- Dose Range Finding Test
In the dose range finding test cuprous thiocyanate was administered to one male and one female at each of 7 dose levels. The dose levels investigated were 100, 500, 1000, 2000, 3000, 4000 and 5000 mg/kg bw.
The rats were observed frequently on the day of dosing and for 14 days following dosing. They were weighed immediately prior to dosing and at the end of the observation period. Each animal was subjected to a gross post mortem examination.
There were no deaths during the 14 day observation period.
There were no clinical signs recorded at any time during the 14 day observation period.
No abnormalities were noted after post mortem examination.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths during the 14 day observation period.
- Clinical signs:
- No clinical signs were recorded at any time during the observation period.
- Body weight:
- All animals gained weight during the study.
- Gross pathology:
- At post mortem, gross examination revealed no abnormalities.
- Other findings:
- The LD50 was greater than 5000 mg/kg bw for both males and females.
Applicant's summary and conclusion
- Conclusions:
- The acute oral LD50 in the rat was greater than 5000 mg/kg bw for males and females.
In this study, copper thiocyanate does not meet the criteria for classification for acute oral toxicity according to Annex VI of Commission Directive 2001/59/EC. - Executive summary:
The execution of this type of short-term study is not individually inspected by the Quality Assurance Department. The processes involved are inspected at intervals according to a pre-determined schedule.
The report has been audited by IRI Quality Assurance Personnel according to the appropriate Standard Operating Procedures and is considered to describe the methods and procedure used in the study. The reported results accurately reflect the original data of the study.
The acute oral LD50 in the rat was greater than 5000 mg/kg bw for males and females.
In this study, copper thiocyanate does not meet the criteria for classification for acute oral toxicity according to Annex VI of Commission Directive 2001/59/EC.
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