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EC number: 946-308-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- august 31, 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Version / remarks:
- Federal guidelines: pesticide assessment guidelines; Part 81-2 November 1984
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Cocamidopropyl PG-dimonium chloride
- Cas Number:
- 136920-08-6
- Molecular formula:
- C20-30H43-63ClN2O2 range
- IUPAC Name:
- Cocamidopropyl PG-dimonium chloride
- Test material form:
- other: aqueous solution
- Details on test material:
- Lot# HH105P
Cocamidopropyl PG dimonium chloride
Lexquat AMG-WC
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Healthy, USDA certified New Zealand albino rabbits were received from Davidson's Mill Farm, South Brunswick, NJ. Five male and five female rabbits were selected for test based on health status and body weight. The weight ranges for males and females were 2.5-3.4 and 2.3-2.5 kg respectively.
acclimatation period: 13, 49, 56, 66 days
Caging individually in suspended stainless steel caging with mesh floors
Temperature 20.5 - 22.7
Food: pelleted Purina Rabbit Chow ad-libitum
Water: tap-water supplied by automatic water system
identification: a number was allocated to each rabbit on receipt.
application day: on August 16, 1989, the test substance was applied to the test site of each individual rabbit and acculated with a non-permeable patch for 24 hrs.
Sacrifice and necropsy of survicors: August 30, 1989
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Following the adaptation period, 5 males and 5 females were prepared by clipping the skin free of hair over approximately 10% of the body surface (dorsal and ventral surfaces from scapular to pelvic area). A non-permeable adhesive-backed gauze patch containing 2g/kg bw of the test material (applied as received, undiluted) was placed over a 4-5 cm2 area on each rabbit. The patches and entire trunk of each rabbit were then wrapped with an elastic cloth to aid in maintaining test patch position to minimze evaporation. Neck collars were then placed on each rabbit. After 24 hrs of exposure to the test material, the patches and collars were removed and the exposed surface was gently wiped clean of any residual test material.
- Duration of exposure:
- 24 hrs
- Doses:
- 2 g/kg bw
- No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- The rabbits were observed for gross toxicity and mortality 1, 2, and 4 hours after test material application. Thereafter, they were observed at least once daily for the remainder of the 14-day test period.
Feed and water were provided ad-libitum thoughout the 14 day period. The body weight of each rabbit were recorded on the day of dosing, at 7 and 14 days post dosing.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Body weight:
- As of day 7, two rabbits lost weight. All others maintained their weights and gained slightly.
- Gross pathology:
- Erythema and edema were noted at all test sites 24 hrs after application of the test material. Thickening of the skin, discolorization and possible eschar were also noted during the 7 days following application.
several animals exhibited moist facial staining and several had reduced feed consumption and fecal output.
Observations are continuing until termination on day 14.
Applicant's summary and conclusion
- Conclusions:
- The Single Dose Acute Dermal Toxicity LD50 is greater than 2.0 g/kg bw when applied as received undiluted.
- Executive summary:
To determine whether a single dose of 2 g of test substance per kg of bodyweight is toxic when applied dermally for 24 hrs to the skin of rabbits.
Following the adaptation period, 5 males and 5 females were occluded with 2g/kg bw of test material, applied as received, undiluted, for 24hrs. The rabbits were observed for gross toxicity and mortality 1, 2, and 4 hours after test material application. Thereafter, they were observed at least once daily for the remainder of the 14-day test period.
All animal survived. As of day 7, two rabbits lost weight. All others maintained their weights and gained slightly.
Erythema and edema were noted at all test sites 24 hrs after application of the test material. Thickening of the skin, discolorization and possible eschar were also noted during the 7 days following application.
several animals exhibited moist facial staining and several had reduced feed consumption and fecal output.
Observations are continuing until termination on day 14.
The Single Dose Acute Dermal Toxicity LD50 is greater than 2.0 g/kg bw when applied as received undiluted.
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