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EC number: 946-308-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- december 29, 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 797.1300 (Aquatic Invertebrate Acute Toxicity Test, Freshwater Daphnids)
- Version / remarks:
- 40 CFR Part 797.1300 and 50 FR 39321, 9/27/85 "Daphnid acute toxicity test"
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cocamidopropyl PG-dimonium chloride
- Cas Number:
- 136920-08-6
- Molecular formula:
- C20-30H43-63ClN2O2 range
- IUPAC Name:
- Cocamidopropyl PG-dimonium chloride
- Test material form:
- other: aqueous solution
- Details on test material:
- Lot# HH105P
Cocamidopropyl PG dimonium chloride
Lexquat AMG-WC
Constituent 1
- Specific details on test material used for the study:
- sample storage in ambient laboratory 21C, sealed product container
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- US EPA (NPDES) Probit Analysis Version 1.2
Test solutions
- Details on test solutions:
- Exposure volume 15 mL
Replication: 5 daphnids/replicate, 4 replicates/treatment
Concentrations: 0.10, 0.18, 0.32, 0.56, and 1.0 ppm nominal
Test organisms
- Test organisms (species):
- Daphnia pulex
- Details on test organisms:
- organism age < 24 hrs at test initiation
organism history: USTC 57th generation, 5th brood, 6/19/89
Feeding regime: none during test
Study design
- Test type:
- static
- Water media type:
- freshwater
- Remarks:
- Round valley reservoir, Lebanon, NJ activated carbon stripped and 0.45micron filtered
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 120 mg/L CaCO3
- Test temperature:
- 20 +/- 2 C
- pH:
- pH (24hrs) = 8.3
pH (48hrs) = 7.8 - Dissolved oxygen:
- 9.0 mg/L at both 24 hr and 48 hr test
- Salinity:
- alkalinity: 50 mg/L CaCO3
- Conductivity:
- At 24hr test: 110 microm hos
At 48hr test: 120 microm hos - Nominal and measured concentrations:
- nominal concentrations: 0.10 / 0.18 / 0.32 / 0.56 / 1.0 ppm
- Details on test conditions:
- Aeration: aerate by mixing test solutions to saturation prior to test; no aeration during test required.
test vessels: 18 x 150 mm glass tubes with Kaput caps
Illumination: 16:8 hour light/dark cycle fluorescent, 50 to 100 ft-candles (lab ambient) - Reference substance (positive control):
- yes
- Remarks:
- diluent, no solvent required
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.6 other: ppm
- Nominal / measured:
- nominal
- Basis for effect:
- mortality
- Details on results:
- The LC50 (48hrs) = 0.60 ppm obtained represents toxicity caused solely by the product. Control mortality was absent and a consistent trend of increasing mortality with increasing product concentration was observed.
Adsorption of the product to exposure chambers may have occured during the test. However daily renewal of test concentrations mitigated these effects, if ony partially.
Chemical confirmation of nominal concentrations was not achieved however the LC50 estimate, are considered reasonably accurate and representative of the type of moiety. - Results with reference substance (positive control):
- No moratlity after 48hr test
- Reported statistics and error estimates:
- HPLC determination of nominal, low, high, and control concentrations was attempted. Frozen, coded samples were sent to the Sponsor July 12, 1989, but were not analysed until October 1989. In addition, the results were questionable since:
1) controls had detectable levels of test substance that should not in theory be present
2) analysed amount of products in test concentrations samples were from one to three orders of magnitude different (lower) from the nominal concentrations intended wuthou any obvious trend, or the levels were undetectable,
3) the methods could not distinguish among the three componds tested and may not be accurate at the low levels tested. Hence the chemical confirmation method may be flawed or the sample storage may have affected the results of chemical analysis or both.
Applicant's summary and conclusion
- Conclusions:
- 48 hr LC50= 0.60 ppm nominal concentration (95% confidence limits = 0.51 - 0.72)
- Executive summary:
Using 40 CFR Part 797.1300 and 50 FR 39321, 9/27/85 "Daphnid acute toxicity test", the toxicity to aquatic invertebrates (Daphnia Pulex) has been described by nominal concentration in a 48 hr test. The result is:
48 hr LC50= 0.60 ppm nominal concentration (95% confidence limits = 0.51 - 0.72)
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