Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-023-8 | CAS number: 50-28-2
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- other: clinical data
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: endogenous human steroidal estrogen and approved drug with widespread therapeutic use for many years
Data source
Materials and methods
- Endpoint addressed:
- skin sensitisation
Results and discussion
- Results:
- 17 ß-estradiol is an estrogenic hormone occuring naturally in humans. Synthetic 17 ß-estradiol is a well-known drug substance and constituent of numerous approved drug products which have been in therapeutic use for many decades and the vast amount of clinical experience gained in its continued and widespread therapeutic use gives no evidence that 17 ß-estradiol, has a significant skin sensitizing potential.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
