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EC number: 204-486-7 | CAS number: 121-61-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation:
The dermal irritation potential of N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor. N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)was estimated to be not irritating to the skin of New Zealand White rabbits. Based on the estimated result, N-(4-sulfamoylphenyl)acetamide can be classified under the category ˋ Not Classified’ as per CLP regulation.
Eye irritation:
The ocular irritation potential of N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor. The substance N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)was estimated to be not irritating into the eyes of New Zealand White rabbits. Based on the estimated result, N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) can be classified under the category ˋ Not Classified’ as per CLP regulation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox v3.3 and the supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction was done using QSAR Toolbox v3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: N-(4-sulfamoylphenyl)acetamide
- Molecular formula: C8H10N2O3S
- Molecular weight: 214.244 g/mol
- Smiles notation: c1(ccc(NC(C)=O)cc1)S(N)(=O)=O
- InChl: 1S/C8H10N2O3S/c1-6(11)10-7-2-4-8(5-3-7)14(9,12)13/h2-5H,1H3,(H,10,11)(H2,9,12,13)
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- No data available
- Observation period:
- No data available
- Number of animals:
- No data available
- Details on study design:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no skin irritation was observed.
- Interpretation of results:
- other: not irritating
- Conclusions:
- N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)was estimated to be not irritating to the skin of New Zealand White rabbits. Based on the estimated result N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)can be considered to be not irritating to skin.
- Executive summary:
The dermal irritation potential of N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor. N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)was estimated to be not irritating to the skin of New Zealand White rabbits. Based on the estimated result, N-(4-sulfamoylphenyl)acetamide can be classified under the category ˋ Not Classified’ as per CLP regulation.
Reference
Estimation
method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((((((((((("a"
or "b" or "c" )
and ("d"
and (
not "e")
)
)
and ("f"
and (
not "g")
)
)
and ("h"
and (
not "i")
)
)
and ("j"
and (
not "k")
)
)
and ("l"
and (
not "m")
)
)
and "n" )
and ("o"
and (
not "p")
)
)
and ("q"
and (
not "r")
)
)
and "s" )
and "t" )
and ("u"
and "v" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Acylation AND Acylation >>
Acylation involving an activated (glucuronidated) carboxamide group AND
Acylation >> Acylation involving an activated (glucuronidated)
carboxamide group >> Carboxylic Acid Amides AND Acylation >> Acylation
involving an activated (glucuronidated) sulfonamide group AND Acylation
>> Acylation involving an activated (glucuronidated) sulfonamide group
>> Arenesulfonamides AND Acylation >> Direct acylation involving a
leaving group AND Acylation >> Direct acylation involving a leaving
group >> Carboxylic Acid Amides AND Acylation >> Ester aminolysis AND
Acylation >> Ester aminolysis >> Amides AND AN2 AND AN2 >> Michael-type
addition to quinoid structures AND AN2 >> Michael-type addition to
quinoid structures >> Carboxylic Acid Amides AND AN2 >> Nucleophilic
addition at polarized N-functional double bond AND AN2 >> Nucleophilic
addition at polarized N-functional double bond >> Arenesulfonamides by
Protein binding by OASIS v1.4
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Acylation AND Acylation >>
Direct Acylation Involving a Leaving group AND Acylation >> Direct
Acylation Involving a Leaving group >> Acetates by Protein binding by
OECD
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Amides by Aquatic toxicity
classification by ECOSAR
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> Direct
Addition of an Acyl Halide OR Acylation >> Direct Addition of an Acyl
Halide >> Acyl halide OR Acylation >> P450 Mediated Activation to
Isocyanates or Isothiocyanates OR Acylation >> P450 Mediated Activation
to Isocyanates or Isothiocyanates >> Formamides OR Michael addition OR
Michael addition >> P450 Mediated Activation of Heterocyclic Ring
Systems OR Michael addition >> P450 Mediated Activation of Heterocyclic
Ring Systems >> Furans OR Michael addition >> P450 Mediated Activation
to Quinones and Quinone-type Chemicals OR Michael addition >> P450
Mediated Activation to Quinones and Quinone-type Chemicals >> Alkyl
phenols OR Michael addition >> P450 Mediated Activation to Quinones and
Quinone-type Chemicals >> Arenes OR Michael addition >> P450 Mediated
Activation to Quinones and Quinone-type Chemicals >> Hydroquinones OR
Michael addition >> Polarised Alkenes-Michael addition OR Michael
addition >> Polarised Alkenes-Michael addition >> Alpha, beta-
unsaturated amides OR Michael addition >> Polarised Alkenes-Michael
addition >> Alpha, beta- unsaturated esters OR Schiff base formers OR
Schiff base formers >> Chemicals Activated by P450 to Glyoxal OR Schiff
base formers >> Chemicals Activated by P450 to Glyoxal >> Ethanolamines
(including morpholine) OR Schiff base formers >> Chemicals Activated by
P450 to Glyoxal >> Ethylenediamines (including piperazine) OR Schiff
base formers >> Direct Acting Schiff Base Formers OR Schiff base formers
>> Direct Acting Schiff Base Formers >> Alpha-beta-dicarbonyl OR Schiff
base formers >> Direct Acting Schiff Base Formers >> Mono aldehydes OR
SN1 OR SN1 >> Carbenium Ion Formation OR SN1 >> Carbenium Ion Formation
>> Allyl benzenes OR SN1 >> Carbenium Ion Formation >> Hydrazine OR SN1
>> Iminium Ion Formation OR SN1 >> Iminium Ion Formation >> Aliphatic
tertiary amines OR SN1 >> Nitrenium Ion formation OR SN1 >> Nitrenium
Ion formation >> Aromatic azo OR SN1 >> Nitrenium Ion formation >>
Aromatic nitro OR SN1 >> Nitrenium Ion formation >> Aromatic phenylureas
OR SN1 >> Nitrenium Ion formation >> Primary (unsaturated) heterocyclic
amine OR SN1 >> Nitrenium Ion formation >> Primary aromatic amine OR SN1
>> Nitrenium Ion formation >> Tertiary aromatic amine OR SN1 >>
Nitrenium Ion formation >> Unsaturated heterocyclic azo OR SN2 OR SN2 >>
Direct Acting Epoxides and related OR SN2 >> Direct Acting Epoxides and
related >> Epoxides OR SN2 >> P450 Mediated Epoxidation OR SN2 >> P450
Mediated Epoxidation >> Coumarins OR SN2 >> SN2 at an sp3 Carbon atom OR
SN2 >> SN2 at an sp3 Carbon atom >> Aliphatic halides OR SN2 >> SN2 at
an sp3 Carbon atom >> Phosphates OR SN2 >> SN2 at an sp3 Carbon atom >>
Sulfonates by DNA binding by OECD
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Non binder, impaired OH or NH2
group OR Non binder, MW>500 OR Non binder, non cyclic structure OR
Strong binder, OH group OR Very strong binder, OH group OR Weak binder,
OH group by Estrogen Receptor Binding
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Acylation AND Acylation >>
Acylation involving an activated (glucuronidated) carboxamide group AND
Acylation >> Acylation involving an activated (glucuronidated)
carboxamide group >> Carboxylic Acid Amides AND Acylation >> Acylation
involving an activated (glucuronidated) sulfonamide group AND Acylation
>> Acylation involving an activated (glucuronidated) sulfonamide group
>> Arenesulfonamides AND Acylation >> Direct acylation involving a
leaving group AND Acylation >> Direct acylation involving a leaving
group >> Carboxylic Acid Amides AND Acylation >> Ester aminolysis AND
Acylation >> Ester aminolysis >> Amides AND AN2 AND AN2 >> Michael-type
addition to quinoid structures AND AN2 >> Michael-type addition to
quinoid structures >> Carboxylic Acid Amides AND AN2 >> Nucleophilic
addition at polarized N-functional double bond AND AN2 >> Nucleophilic
addition at polarized N-functional double bond >> Arenesulfonamides by
Protein binding by OASIS v1.4
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Acylation >> Acylation involving
an activated (glucuronidated) ester group OR Acylation >> Acylation
involving an activated (glucuronidated) ester group >> Arenecarboxylic
Acid Esters OR Acylation >> Direct acylation involving a leaving group
>> Anhydrides (sulphur analogues of anhydrides) OR Acylation >> Direct
acylation involving a leaving group >> N-Carbonylsulfonamides OR
Acylation >> Direct acylation involving a leaving group >>
N-Haloacylamides OR Acylation >> Direct acylation involving a leaving
group >> Sulphonyl halides or cyanides OR Acylation >> Ester aminolysis
or thiolysis OR Acylation >> Ester aminolysis or thiolysis >> Activated
aryl esters OR Acylation >> Ring opening acylation OR Acylation >> Ring
opening acylation >> Active cyclic agents OR AN2 >> Michael addition to
activated double bonds OR AN2 >> Michael addition to activated double
bonds >> alpha,beta-Unsaturated Carbonyls and Related Compounds OR AN2
>> Michael addition to activated double bonds in heterocyclic ring
systems OR AN2 >> Michael addition to activated double bonds in
heterocyclic ring systems >> Pyrazolone and Pyrazolidine Derivatives OR
AN2 >> Michael addition to alpha, beta-unsaturated acids and esters OR
AN2 >> Michael addition to alpha, beta-unsaturated acids and esters >>
alpha,beta-Unsaturated Carboxylic Acids and Esters OR AN2 >> Michael
type addition to activated double bond of pyrimidine bases OR AN2 >>
Michael type addition to activated double bond of pyrimidine bases >>
Pyrimidines and Purines OR AN2 >> Michael type nucleophilic addition and
Schiff base formation OR AN2 >> Michael type nucleophilic addition and
Schiff base formation >> Halogenated Vicinal Hydrocarbons OR AN2 >>
Michael-type addition to quinoid structures >> N-Substituted Aromatic
Amines OR AN2 >> Schiff base formation with carbonyl compounds (AN2) OR
AN2 >> Schiff base formation with carbonyl compounds (AN2) >> Pyrazolone
and Pyrazolidine Derivatives OR AN2 >> Schiff base formation with
carbonyl group of pyrimidine and purine bases OR AN2 >> Schiff base
formation with carbonyl group of pyrimidine and purine bases >>
Pyrimidines and Purines OR Michael addition OR Michael addition >>
Michae addition on quinoide type compounds OR Michael addition >> Michae
addition on quinoide type compounds >> Quinone methide(s)/imines;
Quinoide oxime structure; Nitroquinones, Naphthoquinone(s)/imines OR
Michael addition >> Michael addition on conjugated systems with electron
withdrawing group OR Michael addition >> Michael addition on conjugated
systems with electron withdrawing group >> alpha,beta-Carbonyl compounds
with polarized double bonds OR Michael addition >> Michael addition on
conjugated systems with electron withdrawing group >> Conjugated systems
with electron withdrawing groups OR No alert found OR Nucleophilic
addition OR Nucleophilic addition >> Addition to carbon-hetero double
bonds OR Nucleophilic addition >> Addition to carbon-hetero double bonds
>> Ketones OR Radical reactions OR Radical reactions >> ROS Generation
OR Radical reactions >> ROS Generation >> Sterically Hindered Piperidine
Derivatives OR Schiff base formation OR Schiff base formation >> Schiff
base on pyrazolones and pyrazolidinones OR Schiff base formation >>
Schiff base on pyrazolones and pyrazolidinones >> Pyrazolones and
Pyrazolidinones OR SN2 OR SN2 >> Interchange reaction with sulphur
containing compounds OR SN2 >> Interchange reaction with sulphur
containing compounds >> Thiols and disulfide compounds OR SN2 >>
Nucleophilic substitution at sp3 carbon atom OR SN2 >> Nucleophilic
substitution at sp3 carbon atom >> alpha-Activated haloalkanes OR SN2
>> Nucleophilic type substitution together with ring-opening of an
episulfonium ion intermediate OR SN2 >> Nucleophilic type substitution
together with ring-opening of an episulfonium ion intermediate >>
Halogenated Vicinal Hydrocarbons OR SN2 >> SN2 Reaction at a sp3 carbon
atom OR SN2 >> SN2 Reaction at a sp3 carbon atom >> Activated alkyl
esters and thioesters OR SNVinyl OR SNVinyl >> SNVinyl at a vinylic
(sp2) carbon atom OR SNVinyl >> SNVinyl at a vinylic (sp2) carbon atom
>> Vinyl type compounds with electron withdrawing groups by Protein
binding by OASIS v1.4
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Acylation AND Acylation >>
Direct Acylation Involving a Leaving group AND Acylation >> Direct
Acylation Involving a Leaving group >> Acetates by Protein binding by
OECD
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Acylation >> Direct Acylation
Involving a Leaving group >> Azlactone OR No alert found OR SN2 OR SN2
>> SN2 reaction at sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon
atom >> Alkyl diazo by Protein binding by OECD
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules (GSH) by Protein binding potency
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Moderately reactive (GSH) OR
Moderately reactive (GSH) >> 2-Vinyl carboxamides (MA) by Protein
binding potency
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as No superfragment by
Superfragments ONLY
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Inclusion rules not met by Eye
irritation/corrosion Inclusion rules by BfR
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Pyrrolidones by Eye
irritation/corrosion Inclusion rules by BfR
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Non-Metals by Groups of elements
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Halogens by Groups of elements
Domain
logical expression index: "s"
Similarity
boundary:Target:
CC(=O)Nc1ccc(S(N)(=O)=O)cc1
Threshold=30%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "t"
Similarity
boundary:Target:
CC(=O)Nc1ccc(S(N)(=O)=O)cc1
Threshold=40%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "u"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -0.852
Domain
logical expression index: "v"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 1.16
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- Data is from OECD QSAR toolbox v3.3 and the supporting QMRF report has been attached
- Qualifier:
- according to guideline
- Guideline:
- other: estimated below
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox v3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: N-(4-sulfamoylphenyl)acetamide
- Molecular formula: C8H10N2O3S
- Molecular weight: 214.244 g/mol
- Smiles notation: c1(ccc(NC(C)=O)cc1)S(N)(=O)=O
- InChl: 1S/C8H10N2O3S/c1-6(11)10-7-2-4-8(5-3-7)14(9,12)13/h2-5H,1H3,(H,10,11)(H2,9,12,13)
- Substance type: Organic
- Physical state: Solid - Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data available
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- No data available
- Duration of treatment / exposure:
- No data available
- Observation period (in vivo):
- No data available
- Duration of post- treatment incubation (in vitro):
- No data available
- Number of animals or in vitro replicates:
- No data available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no eye irritation was observed.
- Interpretation of results:
- other: not irritating
- Conclusions:
- The substance N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)was estimated to be not irritating into the eyes of New Zealand White rabbits. Based on the estimated result N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)can be considered to be not irritating to eye.
- Executive summary:
The ocular irritation potential of N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)was estimated using OECD QSAR toolbox v3.3 with logPow as the primary descriptor. The substance N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)was estimated to be not irritating into the eyes of New Zealand White rabbits. Based on the estimated result, N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) can be classified under the category ˋ Not Classified’ as per CLP regulation.
Reference
Estimation
method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((((((((((("a"
or "b" or "c" )
and ("d"
and (
not "e")
)
)
and ("f"
and (
not "g")
)
)
and ("h"
and (
not "i")
)
)
and ("j"
and (
not "k")
)
)
and ("l"
and (
not "m")
)
)
and ("n"
and (
not "o")
)
)
and ("p"
and (
not "q")
)
)
and "r" )
and "s" )
and "t" )
and ("u"
and "v" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Acylation AND Acylation >>
Acylation involving an activated (glucuronidated) carboxamide group AND
Acylation >> Acylation involving an activated (glucuronidated)
carboxamide group >> Carboxylic Acid Amides AND Acylation >> Acylation
involving an activated (glucuronidated) sulfonamide group AND Acylation
>> Acylation involving an activated (glucuronidated) sulfonamide group
>> Arenesulfonamides AND Acylation >> Direct acylation involving a
leaving group AND Acylation >> Direct acylation involving a leaving
group >> Carboxylic Acid Amides AND Acylation >> Ester aminolysis AND
Acylation >> Ester aminolysis >> Amides AND AN2 AND AN2 >> Michael-type
addition to quinoid structures AND AN2 >> Michael-type addition to
quinoid structures >> Carboxylic Acid Amides AND AN2 >> Nucleophilic
addition at polarized N-functional double bond AND AN2 >> Nucleophilic
addition at polarized N-functional double bond >> Arenesulfonamides by
Protein binding by OASIS v1.4
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Acylation AND Acylation >>
Direct Acylation Involving a Leaving group AND Acylation >> Direct
Acylation Involving a Leaving group >> Acetates by Protein binding by
OECD
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as Amides by Aquatic toxicity
classification by ECOSAR
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OASIS v.1.4
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as AN2 OR AN2 >> Michael-type
addition, quinoid structures OR AN2 >> Michael-type addition, quinoid
structures >> Quinones and Trihydroxybenzenes OR AN2 >> Carbamoylation
after isocyanate formation OR AN2 >> Carbamoylation after isocyanate
formation >> N-Hydroxylamines OR AN2 >> Michael-type addition on alpha,
beta-unsaturated carbonyl compounds OR AN2 >> Michael-type addition on
alpha, beta-unsaturated carbonyl compounds >> Four- and Five-Membered
Lactones OR AN2 >> Nucleophilic addition reaction with
cycloisomerization OR AN2 >> Nucleophilic addition reaction with
cycloisomerization >> Hydrazine Derivatives OR AN2 >> Schiff base
formation OR AN2 >> Schiff base formation >> Polarized Haloalkene
Derivatives OR AN2 >> Schiff base formation by aldehyde formed after
metabolic activation OR AN2 >> Schiff base formation by aldehyde formed
after metabolic activation >> Geminal Polyhaloalkane Derivatives OR AN2
>> Shiff base formation after aldehyde release OR AN2 >> Shiff base
formation after aldehyde release >> Specific Acetate Esters OR AN2 >>
Thioacylation via nucleophilic addition after cysteine-mediated
thioketene formation OR AN2 >> Thioacylation via nucleophilic addition
after cysteine-mediated thioketene formation >> Haloalkenes with
Electron-Withdrawing Groups OR AN2 >> Thioacylation via nucleophilic
addition after cysteine-mediated thioketene formation >> Polarized
Haloalkene Derivatives OR Non-covalent interaction OR Non-covalent
interaction >> DNA intercalation OR Non-covalent interaction >> DNA
intercalation >> Amino Anthraquinones OR Non-covalent interaction >> DNA
intercalation >> Coumarins OR Non-covalent interaction >> DNA
intercalation >> DNA Intercalators with Carboxamide and Aminoalkylamine
Side Chain OR Non-covalent interaction >> DNA intercalation >>
Fused-Ring Nitroaromatics OR Non-covalent interaction >> DNA
intercalation >> Fused-Ring Primary Aromatic Amines OR Non-covalent
interaction >> DNA intercalation >> N-Hydroxyethyl Lactams OR
Non-covalent interaction >> DNA intercalation >> Organic Azides OR
Non-covalent interaction >> DNA intercalation >> Polycyclic Aromatic
Hydrocarbon and Naphthalenediimide Derivatives OR Non-covalent
interaction >> DNA intercalation >> Quinones and Trihydroxybenzenes OR
Non-specific OR Non-specific >> Incorporation into DNA/RNA, due to
structural analogy with nucleoside bases OR Non-specific >>
Incorporation into DNA/RNA, due to structural analogy with nucleoside
bases >> Specific Imine and Thione Derivatives OR Radical OR Radical
>> Generation of ROS by glutathione depletion (indirect) OR Radical >>
Generation of ROS by glutathione depletion (indirect) >> Haloalkanes
Containing Heteroatom OR Radical >> Radical mechanism by ROS formation
OR Radical >> Radical mechanism by ROS formation >> Organic Azides OR
Radical >> Radical mechanism via ROS formation (indirect) OR Radical >>
Radical mechanism via ROS formation (indirect) >> Amino Anthraquinones
OR Radical >> Radical mechanism via ROS formation (indirect) >>
Coumarins OR Radical >> Radical mechanism via ROS formation (indirect)
>> Fused-Ring Nitroaromatics OR Radical >> Radical mechanism via ROS
formation (indirect) >> Fused-Ring Primary Aromatic Amines OR Radical >>
Radical mechanism via ROS formation (indirect) >> Geminal Polyhaloalkane
Derivatives OR Radical >> Radical mechanism via ROS formation (indirect)
>> Hydrazine Derivatives OR Radical >> Radical mechanism via ROS
formation (indirect) >> N-Hydroxylamines OR Radical >> Radical mechanism
via ROS formation (indirect) >> Nitro Azoarenes OR Radical >> Radical
mechanism via ROS formation (indirect) >> Nitroarenes with Other Active
Groups OR Radical >> Radical mechanism via ROS formation (indirect) >>
Nitrophenols, Nitrophenyl Ethers and Nitrobenzoic Acids OR Radical >>
Radical mechanism via ROS formation (indirect) >> p-Substituted
Mononitrobenzenes OR Radical >> Radical mechanism via ROS formation
(indirect) >> Quinones and Trihydroxybenzenes OR Radical >> Radical
mechanism via ROS formation (indirect) >> Single-Ring Substituted
Primary Aromatic Amines OR Radical >> Radical mechanism via ROS
formation (indirect) >> Specific Imine and Thione Derivatives OR SN1 OR
SN1 >> Alkylation after metabolically formed carbenium ion species OR
SN1 >> Alkylation after metabolically formed carbenium ion species >>
Polycyclic Aromatic Hydrocarbon and Naphthalenediimide Derivatives OR
SN1 >> Nucleophilic attack after carbenium ion formation OR SN1 >>
Nucleophilic attack after carbenium ion formation >> Specific Acetate
Esters OR SN1 >> Nucleophilic attack after diazonium or carbenium ion
formation OR SN1 >> Nucleophilic attack after diazonium or carbenium ion
formation >> Nitroarenes with Other Active Groups OR SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation OR SN1 >> Nucleophilic
attack after metabolic nitrenium ion formation >> Amino Anthraquinones
OR SN1 >> Nucleophilic attack after metabolic nitrenium ion formation >>
Fused-Ring Primary Aromatic Amines OR SN1 >> Nucleophilic attack after
nitrene formation OR SN1 >> Nucleophilic attack after nitrene formation
>> Organic Azides OR SN1 >> Nucleophilic attack after nitrenium ion
formation OR SN1 >> Nucleophilic attack after nitrenium ion formation >>
N-Hydroxylamines OR SN1 >> Nucleophilic attack after nitrenium ion
formation >> Single-Ring Substituted Primary Aromatic Amines OR SN1 >>
Nucleophilic attack after reduction and nitrenium ion formation OR SN1
>> Nucleophilic attack after reduction and nitrenium ion formation >>
Fused-Ring Nitroaromatics OR SN1 >> Nucleophilic attack after reduction
and nitrenium ion formation >> Nitro Azoarenes OR SN1 >> Nucleophilic
attack after reduction and nitrenium ion formation >> Nitroarenes with
Other Active Groups OR SN1 >> Nucleophilic attack after reduction and
nitrenium ion formation >> Nitrophenols, Nitrophenyl Ethers and
Nitrobenzoic Acids OR SN1 >> Nucleophilic attack after reduction and
nitrenium ion formation >> p-Substituted Mononitrobenzenes OR SN1 >>
Nucleophilic substitution on diazonium ion OR SN1 >> Nucleophilic
substitution on diazonium ion >> Specific Imine and Thione Derivatives
OR SN2 OR SN2 >> Acylation OR SN2 >> Acylation >> N-Hydroxylamines OR
SN2 >> Acylation >> Specific Acetate Esters OR SN2 >> Acylation
involving a leaving group after metabolic activation OR SN2 >> Acylation
involving a leaving group after metabolic activation >> Geminal
Polyhaloalkane Derivatives OR SN2 >> Alkylation OR SN2 >> Alkylation >>
Alkylphosphates, Alkylthiophosphates and Alkylphosphonates OR SN2 >>
Alkylation, direct acting epoxides and related after P450-mediated
metabolic activation OR SN2 >> Alkylation, direct acting epoxides and
related after P450-mediated metabolic activation >> Haloalkenes with
Electron-Withdrawing Groups OR SN2 >> Alkylation, direct acting epoxides
and related after P450-mediated metabolic activation >> Polarized
Haloalkene Derivatives OR SN2 >> Alkylation, direct acting epoxides and
related after P450-mediated metabolic activation >> Polycyclic Aromatic
Hydrocarbon and Naphthalenediimide Derivatives OR SN2 >> Alkylation,
nucleophilic substitution at sp3-carbon atom OR SN2 >> Alkylation,
nucleophilic substitution at sp3-carbon atom >> Haloalkanes Containing
Heteroatom OR SN2 >> Alkylation, nucleophilic substitution at sp3-carbon
atom >> Sulfonates and Sulfates OR SN2 >> Alkylation, ring opening SN2
reaction OR SN2 >> Alkylation, ring opening SN2 reaction >> Four- and
Five-Membered Lactones OR SN2 >> Direct acting epoxides formed after
metabolic activation OR SN2 >> Direct acting epoxides formed after
metabolic activation >> Coumarins OR SN2 >> Direct acting epoxides
formed after metabolic activation >> Quinoline Derivatives OR SN2 >>
Direct acylation involving a leaving group OR SN2 >> Direct acylation
involving a leaving group >> Acyl Halides OR SN2 >> Direct nucleophilic
attack on diazonium cation OR SN2 >> Direct nucleophilic attack on
diazonium cation >> Hydrazine Derivatives OR SN2 >> DNA alkylation OR
SN2 >> DNA alkylation >> Vicinal Dihaloalkanes OR SN2 >> Internal SN2
reaction with aziridinium and/or cyclic sulfonium ion formation
(enzymatic) OR SN2 >> Internal SN2 reaction with aziridinium and/or
cyclic sulfonium ion formation (enzymatic) >> Vicinal Dihaloalkanes OR
SN2 >> Nucleophilic substitution at sp3 Carbon atom OR SN2 >>
Nucleophilic substitution at sp3 Carbon atom >> Haloalkanes Containing
Heteroatom OR SN2 >> Nucleophilic substitution at sp3 Carbon atom >>
Specific Acetate Esters OR SN2 >> Nucleophilic substitution at sp3
carbon atom after thiol (glutathione) conjugation OR SN2 >> Nucleophilic
substitution at sp3 carbon atom after thiol (glutathione) conjugation >>
Geminal Polyhaloalkane Derivatives OR SN2 >> SN2 at an activated carbon
atom OR SN2 >> SN2 at an activated carbon atom >> Quinoline Derivatives
OR SN2 >> SN2 at sp3 and activated sp2 carbon atom OR SN2 >> SN2 at sp3
and activated sp2 carbon atom >> Polarized Haloalkene Derivatives OR SN2
>> SN2 at sulfur atom OR SN2 >> SN2 at sulfur atom >> Sulfonyl Halides
OR SN2 >> SN2 attack on activated carbon Csp3 or Csp2 OR SN2 >> SN2
attack on activated carbon Csp3 or Csp2 >> Nitroarenes with Other Active
Groups by DNA binding by OASIS v.1.4
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as No alert found by DNA binding by
OECD
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Acylation OR Acylation >> P450
Mediated Activation to Isocyanates or Isothiocyanates OR Acylation >>
P450 Mediated Activation to Isocyanates or Isothiocyanates >> Formamides
OR Michael addition OR Michael addition >> P450 Mediated Activation to
Quinones and Quinone-type Chemicals OR Michael addition >> P450 Mediated
Activation to Quinones and Quinone-type Chemicals >> Alkyl phenols OR
Michael addition >> P450 Mediated Activation to Quinones and
Quinone-type Chemicals >> Arenes OR Michael addition >> P450 Mediated
Activation to Quinones and Quinone-type Chemicals >> Hydroquinones OR
Michael addition >> Polarised Alkenes-Michael addition OR Michael
addition >> Polarised Alkenes-Michael addition >> Alpha, beta-
unsaturated amides OR Michael addition >> Polarised Alkenes-Michael
addition >> Alpha, beta- unsaturated esters OR Schiff base formers OR
Schiff base formers >> Chemicals Activated by P450 to Glyoxal OR Schiff
base formers >> Chemicals Activated by P450 to Glyoxal >>
Ethylenediamines (including piperazine) OR SN1 OR SN1 >> Carbenium Ion
Formation OR SN1 >> Carbenium Ion Formation >> Allyl benzenes OR SN1 >>
Iminium Ion Formation OR SN1 >> Iminium Ion Formation >> Aliphatic
tertiary amines OR SN1 >> Nitrenium Ion formation OR SN1 >> Nitrenium
Ion formation >> Aromatic azo OR SN1 >> Nitrenium Ion formation >>
Aromatic nitro OR SN1 >> Nitrenium Ion formation >> Aromatic phenylureas
OR SN1 >> Nitrenium Ion formation >> Primary (unsaturated) heterocyclic
amine OR SN1 >> Nitrenium Ion formation >> Primary aromatic amine OR SN1
>> Nitrenium Ion formation >> Tertiary aromatic amine OR SN1 >>
Nitrenium Ion formation >> Unsaturated heterocyclic azo by DNA binding
by OECD
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as Non binder, without OH or NH2
group by Estrogen Receptor Binding
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as Non binder, impaired OH or NH2
group OR Non binder, MW>500 OR Non binder, non cyclic structure OR
Strong binder, OH group OR Very strong binder, OH group by Estrogen
Receptor Binding
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as Acylation AND Acylation >>
Acylation involving an activated (glucuronidated) carboxamide group AND
Acylation >> Acylation involving an activated (glucuronidated)
carboxamide group >> Carboxylic Acid Amides AND Acylation >> Acylation
involving an activated (glucuronidated) sulfonamide group AND Acylation
>> Acylation involving an activated (glucuronidated) sulfonamide group
>> Arenesulfonamides AND Acylation >> Direct acylation involving a
leaving group AND Acylation >> Direct acylation involving a leaving
group >> Carboxylic Acid Amides AND Acylation >> Ester aminolysis AND
Acylation >> Ester aminolysis >> Amides AND AN2 AND AN2 >> Michael-type
addition to quinoid structures AND AN2 >> Michael-type addition to
quinoid structures >> Carboxylic Acid Amides AND AN2 >> Nucleophilic
addition at polarized N-functional double bond AND AN2 >> Nucleophilic
addition at polarized N-functional double bond >> Arenesulfonamides by
Protein binding by OASIS v1.4
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Acylation >> Direct acylation
involving a leaving group >> Anhydrides (sulphur analogues of
anhydrides) OR Acylation >> Direct acylation involving a leaving group
>> Azlactones and unsaturated lactone derivatives OR Acylation >>
Direct acylation involving a leaving group >> N-Carbonylsulfonamides OR
Acylation >> Ester aminolysis or thiolysis OR Acylation >> Ester
aminolysis or thiolysis >> Activated aryl esters OR Acylation >> Ring
opening acylation OR Acylation >> Ring opening acylation >> Active
cyclic agents OR AN2 >> Michael addition to activated double bonds OR
AN2 >> Michael addition to activated double bonds >>
alpha,beta-Unsaturated Carbonyls and Related Compounds OR AN2 >> Michael
addition to activated double bonds in heterocyclic ring systems OR AN2
>> Michael addition to activated double bonds in heterocyclic ring
systems >> Pyrazolone and Pyrazolidine Derivatives OR AN2 >> Michael
addition to alpha, beta-unsaturated acids and esters OR AN2 >> Michael
addition to alpha, beta-unsaturated acids and esters >>
alpha,beta-Unsaturated Carboxylic Acids and Esters OR AN2 >> Michael
type addition to activated double bond of pyrimidine bases OR AN2 >>
Michael type addition to activated double bond of pyrimidine bases >>
Pyrimidines and Purines OR AN2 >> Michael-type addition to quinoid
structures >> N-Substituted Aromatic Amines OR AN2 >> Schiff base
formation with carbonyl compounds (AN2) OR AN2 >> Schiff base formation
with carbonyl compounds (AN2) >> Pyrazolone and Pyrazolidine Derivatives
OR AN2 >> Schiff base formation with carbonyl group of pyrimidine and
purine bases OR AN2 >> Schiff base formation with carbonyl group of
pyrimidine and purine bases >> Pyrimidines and Purines OR Michael
addition OR Michael addition >> Michae addition on quinoide type
compounds OR Michael addition >> Michae addition on quinoide type
compounds >> Quinone methide(s)/imines; Quinoide oxime structure;
Nitroquinones, Naphthoquinone(s)/imines OR Michael addition >> Michael
addition on conjugated systems with electron withdrawing group OR
Michael addition >> Michael addition on conjugated systems with electron
withdrawing group >> alpha,beta-Carbonyl compounds with polarized double
bonds OR Michael addition >> Michael addition on conjugated systems
with electron withdrawing group >> Conjugated systems with electron
withdrawing groups OR No alert found OR Nucleophilic addition OR
Nucleophilic addition >> Addition to carbon-hetero double bonds OR
Nucleophilic addition >> Addition to carbon-hetero double bonds >>
Ketones OR Radical reactions OR Radical reactions >> ROS Generation OR
Radical reactions >> ROS Generation >> Sterically Hindered Piperidine
Derivatives OR Schiff base formation OR Schiff base formation >> Schiff
base on pyrazolones and pyrazolidinones OR Schiff base formation >>
Schiff base on pyrazolones and pyrazolidinones >> Pyrazolones and
Pyrazolidinones OR SN2 OR SN2 >> Nucleophilic substitution at sp3 carbon
atom OR SN2 >> Nucleophilic substitution at sp3 carbon atom >>
alpha-Activated haloalkanes OR SN2 >> SN2 Reaction at a sp3 carbon atom
OR SN2 >> SN2 Reaction at a sp3 carbon atom >> Activated alkyl esters
and thioesters by Protein binding by OASIS v1.4
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Acylation AND Acylation >>
Direct Acylation Involving a Leaving group AND Acylation >> Direct
Acylation Involving a Leaving group >> Acetates by Protein binding by
OECD
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Acylation >> Direct Acylation
Involving a Leaving group >> Azlactone OR No alert found OR SN2 OR SN2
>> SN2 reaction at sp3 carbon atom OR SN2 >> SN2 reaction at sp3 carbon
atom >> Alkyl diazo by Protein binding by OECD
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules (GSH) by Protein binding potency
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Moderately reactive (GSH) OR
Moderately reactive (GSH) >> 2-Vinyl carboxamides (MA) by Protein
binding potency
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Non-Metals by Groups of elements
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Alkali Earth OR Halogens by
Groups of elements
Domain
logical expression index: "r"
Similarity
boundary:Target:
CC(=O)Nc1ccc(S(N)(=O)=O)cc1
Threshold=20%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "s"
Similarity
boundary:Target:
CC(=O)Nc1ccc(S(N)(=O)=O)cc1
Threshold=30%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "t"
Similarity
boundary:Target:
CC(=O)Nc1ccc(S(N)(=O)=O)cc1
Threshold=40%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization
Domain
logical expression index: "u"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -0.852
Domain
logical expression index: "v"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 1.16
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
Various studies have been investigated for the test chemicalN-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)to observe the potential for dermal irritation to a greater or lesser extent. The studies are based on in vivo experiments in rabbits and guinea pigs for target chemical, N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)and its structurally similar read across substances; Niacinamide (CAS No: -98-92-0) and Acetaminophen (CAS no: 103-90-2).The predicted data using the OECD QSAR toolbox and Danish QSAR database has also been compared with the experimental data and summarized as follows:
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the skin irritation potential was estimated for test chemicalN-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) .The chemical N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)is estimated to be not irritating to skin of New Zealand White rabbits.
According to Danish QSAR database, skin irritation effects were estimated by four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra used for N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9). Based on estimation, no severe skin irritation effects were known when N-(4-sulfamoylphenyl)acetamide was exposed to rabbit skin. Hence, N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) was considered to be not irritating.
The Cosmetic Ingredients Review (CIR, 2005) conducted Preliminary irritation test for structurally similar read across substance Niacinamide(CAS No: -98-92-0) in guinea pigs to determine the concentration suitable for the sensitization study [injection challenge concentration (ICC) and application challenge concentration(ACC)] which supports the above results. In the preliminary test, the guinea pigs were treated intradermally and dermally.8 previously untreated guinea pigs were (4/SEX) were injected intradermally in the clipped and shaved flanks with 0.1ml aliquots of a range of concentration of test substance in physiological saline. 24 hours later, the skin was examined for erythema and edema.The concentration giving slight but perceptible irritation with no oedema was selected as the injection challenge concentration (ICC). Aliquots of 0.1ml using a range of concentration of the test substance in distilled water were applied in small circular areas to the shaved flanks of 4 previously untreated guinea pigs.24 hours later, the skin was examined for erythema and the highest concentration which caused no irritation was selected as the application challenge concentration (ACC). As a result of preliminary studies, the concentration of Niacinamide at which no irritation was observed were 5% for the ICC and 20% for ACC. Since the test chemical did not induce any cutaneous effects at these concentrations, Niacinamide(CAS No: -98-92-0) was considered to be not irritating to the skin of guinea pigs.
The above results were further supported by skin irritation study reported by EUROPEAN COMMISSION – European Chemicals Bureau (2000) onstructurally similar read across substanceAcetaminophen (CAS no: 103-90-2) on the skin of three rabbits in accordance with OECD Guide–line 404 "Acute Dermal Irritation/Corrosion.In this study, 500mg of Acetaminophen was applied on the shaved skin of each rabbit for 4 hours and observed for skin lesions. A very slight erythema was observed on 2 of the 3 rabbits and disappeared after 24h exposition.Since the observed effect were not persisted, the chemical Acetaminophen(CAS no: 103-90-2) was considered to be not irritating to the skin of rabbits.
Based on the available data for the target as well as it read across substances and applying the weight of evidence approach,it can be concluded that N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) was not irritating to skin; and it can be classified under the category “Not Classified” as per CLP regulation.
Eye irritation:
In different studies,N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)has been investigated for potential for ocular irritationto a greater or lesser extent. The studies are based on in vivo experiments in rabbits for target chemicalN-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)and its structurally similar read across substances, Niacinamide (CAS No: -98-92-0)and Acetaminophen (CAS no: 103-90-2).The predicted data using the OECD QSAR toolbox has also been compared with the experimental data and summarized as below;
In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the eye irritation potential was estimated for test chemicalN-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9).The chemical N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9)wass estimated to be not irritating to eyes of New Zealand White rabbits.
The Cosmetic Ingredients Review (CIR, 2005) conducted Low volume eye test for the structurally similar read across substance, Niacinamide(CAS No: -98-92-0) to determine the degree of eye irritancy caused by the chemical. During the test, 16% and 25% of Niacinamide dissolved in water was placed into the eye of New Zealand White rabbits. The maximum average score (MAS) observed was 0.67 and the effects observed were cleared within 10 days. Since the chemical did not produce any acute ocular hazards, Niacinamide(CAS No: -98-92-0) was considered to be non-irritating to the eyes of New Zealand White Rabbits.
The above results were further supported by experimental study reported by EUROPEAN COMMISSION – European Chemicals Bureau (2000) for the structurally similar read across substance, Acetaminophen (CAS no: 103-90-2). The study was performed in accordance with OECD Guideline 405 "Acute Eye Irritation/Corrosion". 100mg of theAcetaminophen was installed into the eye of 3 rabbits and observed for ocular lesions. At 1 hour after the application the conjunctivitis of all 3 rabbits was injected, and was still present in one animal at 24H exposition.Thus on the basis of observed effects, the chemical Acetaminophen(CAS no: 103-90-2) was considered to be not irritating to the eyes of rabbits.
Based on the available data for the target as well as it read across substances and applying the weight of evidence approach,it can be concluded that N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) was not irritating to eyes; and it can be classified under the category “Not Classified” as per CLP regulation.
Justification for classification or non-classification
Based on the available information, N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) is not likely to cause any irritation to eyes and skin.
Hence, N-(4-sulfamoylphenyl)acetamide (CAS No:121-61-9) can be classified under the category “Not Classified" as per CLP regulation.
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