Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-486-7 | CAS number: 121-61-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from publication
- Justification for type of information:
- Data is from United States Department of the Interior, Fred A. Seaton, Secretary Fish and Wildlife Service.
- Qualifier:
- according to guideline
- Guideline:
- other: As per mention below
- Version / remarks:
- No data available
- Deviations:
- not specified
- Principles of method if other than guideline:
- Short term toxicity study of N4-Acetylsulfanilamide on the growth of fishes Petromyzon marinus, Salmo gairdnerii and Lepomis macrochinus for 24 hrs.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material : N-(4-sulfamoylphenyl) acetamide
- Molecular formula : C8H10N2O3S
- Molecular weight : 214.244 g/mol
- Smiles notation : c1(ccc(NC(C)=O)cc1)S(N)(=O)=O
- InChl : 1S/C8H10N2O3S/c1-6(11)10-7-2-4-8(5-3-7)14(9,12)13/h2-5H,1H3,(H,10,11)(H2,9,12,13)
- Substance type: Organic
- Physical state: Solid - Analytical monitoring:
- not specified
- Details on sampling:
- - Concentrations: 5 mg/l (5ppm)
- Sampling method: No data available
- Sample storage conditions before analysis: specimens were maintained in the best possible physical condition until used in the laboratory. - Vehicle:
- yes
- Remarks:
- acetone or alcohol was used as a solvent
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 5 mg/l Chemicals were weighed in calibrated weighing bottles to the nearest milligram on a Volland Speedigram balance. Each concentrated mixture was next added to a predetermined volume of water (as required by actual weight of Sample and desired concentration) and agitated with a Power-Stir to produce a more dilute solution.
Emulsions or suspensions of insoluble compounds were made with the aid of a Waring blender. These prepared solutions, emulsions, or suspensions were added to the test containers in which the experimental animals had already been placed.
- Eluate: No data available
- Differential loading: No data available
- Controls: No data available
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): Acetone or alcohol
- Concentration of vehicle in test medium (stock solution and final test solution(s) or suspension(s) including control(s)): Five cubic centimeters of the indicated solvent was added to each sample.
- Evidence of undissolved material (e.g. precipitate, surface film, etc.): No data available - Test organisms (species):
- other: Petromyzon marinus, Salmo gairdnerii and Lepomis macrochirus
- Details on test organisms:
- TEST ORGANISM
- Common name: Sea lamprey for Petromyzon marinus, Rainbow trout for Salmo gairdnerii and Bluegill sunfish for Lepomis macrochinus
- Source: Stock of local state and federal fish hatcheries.
- Length at study initiation (length definition, mean, range and SD): 3 to 5 inches in total length. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 24 h
- Remarks on exposure duration:
- No data available
- Post exposure observation period:
- No data available
- Hardness:
- No data available
- Test temperature:
- 55° C
- pH:
- 7.5 to 8.2
- Dissolved oxygen:
- 8.6 to 13.7 ppm
- Salinity:
- No data
- Conductivity:
- No data
- Nominal and measured concentrations:
- Measured concentration 5 mg/l Chemicals were weighed in calibrated weighing bottles to the nearest milligram on a Volland Speedigram balance.
- Details on test conditions:
- - Test vessel: Glass battery jar
- Material, size, headspace, fill volume: 10 liter of glass battery jar contain 5 liter of water having the headspace of 5 liter.
- Aeration: These jars were provided with aeration through standard stone air - breakers (al near oxygen saturation, as determined by repeated tests) and were maintained at a constant temp by Immersion in specially constructed constant temperature troughs.
- No. of organisms per vessel: 6
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Other: Twelve of test jars (each containing a substance being assayed) - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: No mortality was obtained
- Details on results:
- - Behavioural abnormalities: No effect was observed.
- Results with reference substance (positive control):
- No data available
- Reported statistics and error estimates:
- No data available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the mortality of fishes Petromyzon marinus, Salmo gairdnerii and Lepomis macrochirus, due to the N4-Acetylsulfanilamide the NOEC was 5 ppm.
- Executive summary:
Short term toxicity study of N4-Acetylsulfanilamide on the growth of fishes Petromyzon marinus, Salmo gairdnerii and Lepomis macrochirus for 24 hrs.Measured concentration of 5 mg/l Chemicals were weighed in calibrated weighing bottles to the nearest milligram on a Volland Speedigram balance. Test performed in the 10 liter of glass battery jar contain 5 liter of water having the headspace of 5 liter. After the exposure of 24 hrs with chemical no any mortality and other effect was observed.
Based on the mortality of fishes Salmo gairdnerii and Lepomis macrochirus, due to the substance, N4-Acetyl -sulfanilamide, the NOEC was 5 ppm.
Reference
Description of key information
Short term toxicity study of N4-Acetylsulfanilamide on the growth of fishes Petromyzon marinus, Salmo gairdnerii and Lepomis macrochirus for 24 hrs.Measured concentration of 5 mg/l Chemicals were weighed in calibrated weighing bottles to the nearest milligram on a Volland Speedigram balance. Test performed in the 10 liter of glass battery jar contain 5 liter of water having the headspace of 5 liter. After the exposure of 24 hrs with chemical no any mortality and other effect was observed. Based on the mortality of fishes Salmo gairdnerii and Lepomis macrochirus, due to the N4-Acetyl -sulfanilamide the NOEC was 5 ppm.
Key value for chemical safety assessment
Additional information
Based on the various experimental data and prediction data for the target chemical study have been reviewed to determine the toxic nature of N-(4-sulfamoylphenyl) acetamide (121-61-9), on the growth of fishes. The studies are as mentioned below:
In the first key study for the target chemical N-(4-sulfamoylphenyl) acetamide (121-61-9) from Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, Short term toxicity study of N4-Acetylsulfanilamide on the growth of fishes Salmo gairdnerii and Lepomis macrochirus for 24 hrs. Measured concentration of 5 mg/l Chemicals were weighed in calibrated weighing bottles to the nearest milligram on a Volland Speedigram balance. Test performed in the 10 liter of glass battery jar contain 5 liter of water having the headspace of 5 liter. After the exposure of 24 hrs. with chemical no any mortality and other effect was observed. Based on the mortality of fishes Salmo gairdnerii and Lepomis macrochirus, due to the N4-Acetyl -sulfanilamide the NOEC was 5 ppm.
Based on the data obtain from various sources i.e from publication and lab report for target and RA chemicals, it can be concluded that the substance N-(4-sulfamoylphenyl) acetamide (121-61-9) is considered to be not toxic to fishes and cannot be classified toxic as per the criteria mentioned in CLP regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.