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Diss Factsheets
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EC number: 203-462-3 | CAS number: 107-10-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 1. The measured atmospheric concentrations are not reported. 2. No ophthalmological examinations were performed. 3. Food consumption was not measured. 4. It is not reported how many nasal sections were examined histopathologically.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Reference Type:
- other: presentation from poster session
- Title:
- Inhalation toxicity of ethylamine (EA) vapor in F-344 rats
- Author:
- Lynch, D., et al.
- Year:
- 1 988
- Bibliographic source:
- Poster session for presentation at the 27th society of toxicology meeting Dallas, TX, February 15-19, 1988
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethylamine
- EC Number:
- 200-834-7
- EC Name:
- Ethylamine
- Cas Number:
- 75-04-7
- IUPAC Name:
- ethanamine
- Details on test material:
- CAS 75-04-7 (ethylamine), solution of 70% (reagent grade) in water
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation:
- Males: 262 +/- 5 g
- Females: 159 +/- 3 g
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Remarks on MMAD:
- MMAD / GSD: no data
- Details on inhalation exposure:
- - Exposure period: 6 h/day, 5 days/week for 24 weeks.
- Route of administration: inhalation (whole body).
- Doses: 0, 18, 184 and 922 mg/m3.
- Air changes: 12-15/hour. - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- - Method: Wilks-Miran infrared analyzer
- Sampling times: 2-4 times per hour - Duration of treatment / exposure:
- 24 weeks
- Frequency of treatment:
- 6 hours/day, 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 10, 100 and 500 ppm (0, 18, 184, and 922 mg/m3)
Basis:
- No. of animals per sex per dose:
- - Number of animals: 30/sex/treatment
- Control animals:
- yes
Examinations
- Observations and examinations performed and frequency:
- - Clinical signs and mortality: twice daily
- Body weight: on the day preceding the first exposure and at 2-week intervals throughout the study period
- Hematology (on 10/sex/treatment only at terminal sacrifice): hemoglobin, hematocrit and complete and differential blood count
- Biochemistry (at 30 day and terminal sacrifice): alanine aminotransferase, aspartate aminotransferase, creatine phosphokinase, lactate dehydrogenase, blood urea nitrogen, creatinine and sorbitol dehydrogenase
- Post-exposure period: No
- Examinations were performed on 6 animals/sex/treatment after 30 and 60 days of exposure and 12-18/sex/treatment at terminal sacrifice. These animals were necropsied and the following analyses were performed:
- Organ weights: lungs, liver, kidney and heart
- Macroscopic: complete gross necropsy
- Microscopic: lungs, liver, kidneys, heart, aorta, spleen, pancreas, tracheobronchial lymph nodes, mesenteric lymph nodes, adrenals, testes, seminal vesicles, ovaries, uterus, trachea, eye, bone marrow (sternum), thymus and nares (at terminal sacrifice only) - Other examinations:
- Electrocardiograms of 10 anesthetized rats at terminal sacrifice.
- Statistics:
- Multiple t-tests, multivariate ANOVA, Kruskal-Wallis test and Chi-square test
Results and discussion
Results of examinations
- Clinical biochemistry findings:
- effects observed, treatment-related
- Details on results:
- TOXIC RESPONSE/EFFECTS BY DOSE LEVEL:
- Mortality: one male and one female at 500 ppm
- Clinical signs: at 500 ppm rats kept their eyes closed and buried their noses in their fur during the entire exposure period
- Body weight gain: significantly reduced at 500 ppm for both males and females
- Clinical chemistry: no treatment-related effects
- Haematology: no treatment-related effects
- Organ weights: at 500 ppm significantly increased relative weights of lung, kidney and heart for both males and females, probably due to the decreased body weights seen at this exposure level
- Gross pathology: no treatment-related signs
- Histopathology: at 500 ppm moderate to marked atrophic rhinitis in the nasal passages, principally in the anterior half and characterized by: purulent exudate of in the nasal meatuses; chronic, active inflammation (often ulcerative), necrosis and loss of the cartilaginous nasal septum, loss of bony turbinates and squamous metaplasia of nasal epithelium
- Other: no consistent treatment-related effects were seen in electrocardiography, although the QT-interval of male rats at 500 ppm was significantly longer than controls
- No adverse effects on male and female gonads were observed
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 100 ppm
- Sex:
- male/female
- Dose descriptor:
- LOAEL
- Effect level:
- 500 ppm
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
NOAEL = 100 ppm (184 mg/m3) based on decreased body weights and histopathological changes of the nasal passages.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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