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EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Chronic toxic encephalopathy in solvent-exposed painters in Denmark 1976-1980: Clinical cases and social consequences after a 5-year follow-up.
- Author:
- Gregersen P, Klausen H, & Elsnab CU
- Year:
- 1 987
- Bibliographic source:
- Am J Ind Med, 11: 399-417.
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In a 5-year follow-up study was described the social consequences for 21 painters who had been diagnosed with chronic toxic encephalopathy. The diagnosis was based on detailed clinical examinations, including interviews about exposure (levels and duration) and subjective symptoms, neuropsychological testing, and neurological and neurophysiological examinations.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Stoddard solvent
- EC Number:
- 232-489-3
- EC Name:
- Stoddard solvent
- Cas Number:
- 8052-41-3
- Molecular formula:
- C10H22
- IUPAC Name:
- stoddard solvent
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- confirmed, but no further information available
- Subjects:
- 21 painters
- Clinical history:
- 21 painters who had been diagnosed with chronic toxic encephalopathy. The diagnosis was based on detailed clinical examinations, including interviews about exposure (levels and duration) and subjective symptoms, neuropsychological testing, and neurological and neurophysiological examinations.
- Route of administration:
- inhalation
- Details on study design:
- In a 5-year follow-up study was described the social consequences for 21 painters who had been diagnosed with chronic toxic encephalopathy. The diagnosis was based on detailed clinical examinations, including interviews about exposure (levels and duration) and subjective symptoms, neuropsychological testing, and neurological and neurophysiological examinations.
Results and discussion
- Results of examinations:
- At the time of diagnosis all the painters had given up their job and five years later 11 worked in other jobs while 10 were receiving the highest disability pension. Clear differences were noted between those who were still working and those who were awarded a pension. The former group were considerably younger, had a history of lower exposure and were less impaired in their intellectual functioning.
Applicant's summary and conclusion
- Conclusions:
- At the time of diagnosis all the painters had given up their job and five years later 11 worked in other jobs while 10 were receiving the highest disability pension. Clear differences were noted between those who were still working and those who were awarded a pension. The former group were considerably younger, had a history of lower exposure and were less impaired in their intellectual functioning.
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