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Diss Factsheets
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EC number: 202-809-6 | CAS number: 100-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: adopted according to OECD SIDS, peer reviewed data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- SIDS Initial Assessment Report (SIAR): 1-Chloro-4-nitrobenzene CAS No: 100-00-5
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- OECD SIDS, UNEP Publications
- Reference Type:
- study report
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: 99.12 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 90 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 3, 10 or 30 mg/kg bw/day dissolved in corn oil
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no data
Examinations
- Statistics:
- Dunnett's and Bartlett's test,modified Mann-Witney test(Bonferroni inequality), Kolmogorov-Smirnov one-tailed test
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- ca. 3 mg/kg bw/day (nominal)
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
one control female died due to physical trauma during dosing.
clinical observation: 30 mg-group, males and females, 10
mg-group, females: general paleness immediately after
dosing, no statistically significant differences in body
weight gain when compared to control rats, food consumption
was sign. higher: females: mid dose, 1 of 13 w, high dose, 5
of 13 w, males: mid dose, 9 of 13 w, high dose, 10 of 13 w
hematological changes: significant increased methemoglobin levels at 3, 10, 30
mg/kg bw: male/female: day 45: 4.2/4.6, 7.8/9.2, 15.0/18.1
%, resp., versus 0.5/0.9 % of controls and day 90: 4.5/4.9,
9.0/9.8, 14.2/18.2 % resp., versus 0.9/1.0 % in controls;
dose-related increase in WBC in males and females (d 45): up
to 44.21 % versus 11.67 %(control), (d 90): up to 12.95 %
(control 10.24 %); dose related increase in reticulocyte
count in males and females: (d 90): up to 39.8 % versus 0.6
% in controls, and in MCV, MCH values in males and females;
significant dose related decrease in erythrocyte count
(d45): up to 5.51 versus 8.49 (control),(d 90): up to 5.58
versus 9.07 in controls, in HGB up to 14.45 % versus 18.78 %
in controls and in HCT, and MCHC values in males and females
clinical chemistry: total protein sign. reduced with increasing dosing d45:
females 10 and 30 mg/kg bw; d90: males 10 and 30 mg/kg bw
and SGPT reduced: males 30 mg/kg bw
urinalysis: At week 13 (= d 90) qualitative increases in levels of
urinary urobilinogen were found in all male and female rats
receiving TS.
gross and histopathology:
spleen: (both sexes, all dosages, dose dependent in
incidence and severity): abnormal coloration, enlargement
increased relative and/or absolute spleen weights, excessive hemosiderin, excessive hemopoiesis, congestion,
vacuolization of the congested red pulp liver: male and female, 30 mg: enlargement, hemosiderosis
and excessive hemopoiesis kidneys: both sexes, dose-dependent: discoloration,
enlargement, hemosiderosis in kidney tubules 30 mg-group: enlargement of the hearts in females, in both
sexes: hyperplasia of bone marrow
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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