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Diss Factsheets
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EC number: 202-809-6 | CAS number: 100-00-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- : lack of details on test substance
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): p-Nitrochlorbenzol
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: W. Ostrop, Meerbusch, Germany
- Weight at study initiation: 2.9 kg
- Diet (e.g. ad libitum): Mümmel Z, Ssniff, Soest, Germany
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 - 18 °C
- Humidity (%): 40 %
- Photoperiod (hrs dark / hrs light): 12 h / 12 h
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- Concentration: 500 mg
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 8d
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: a 2.5 x2.5 cm area
- Gauze pads were loaded with 500mg 1 -chloro-4 -nitrobenzene suspended with 1 or 2 drops of water
- Type of wrap if used: The test areas were covered occlusive with a layer of PVC-film (5 x 5 cm) and adhesive tape (Leukoflex)
REMOVAL OF TEST SUBSTANCE
24 hours
SCORING SYSTEM
According to: Code of Federal Regulations, Title 16, Section 1500.41
reading times, 24,48 72 hours and day 8 post application, control-reading 48 hours and day 8 post appl. was not included in the evaluation
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6/6
- Time point:
- other: 24 and 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- other: after 72 hours score 1
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- other: 24 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- other: 24 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- other: after 72 hours score 1
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days (score 1)
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: 72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- other: 72 hours
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- after 8 days score 3
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- other: 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not reversible
Any other information on results incl. tables
Erythema |
|
Skin irritation / Animal No. |
Total |
Mean |
|||||
Time |
1 |
2 |
3 |
4 |
5 |
6 |
|||
Intact skin |
24h 72h |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
0 0 |
8d |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
|
Scarified skin |
24h 72h |
0 0 |
0 0 |
0 0 |
0 0 |
1 0 |
0 0 |
1 0 |
0.17 0 |
8d |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
Oedema |
|
Skin irritation / Animal No. |
Total |
Mean |
|||||
Time |
1 |
2 |
3 |
4 |
5 |
6 |
|||
Intact skin |
24h 72h |
2 0 |
2 1 |
2 2 |
2 0 |
2 2 |
3 1 |
13 6 |
2.17 1.0 |
8d |
1 |
1 |
2 |
1 |
3 |
1 |
|
|
|
Scarified skin |
24h 72h |
2 0 |
2 1 |
2 2 |
0 0 |
2 2 |
2 1 |
10 6 |
1.67 1.0 |
8d |
1 |
2 |
1 |
1 |
3 |
2 |
|
|
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification:
DSD: not classified
EU-GHS: not classified - Executive summary:
Schreiber (Bayer AG), 1980
The skin irritation potential of 1 -chloro-4 -nitrobenzene was investigated in 6 New Zealand White rabbits conducted comparable to OECD-guideline 404.
A 2.5 x 2.5 cm area of intact shaved animal skin and scarified skin was used to apply the test substance. Gauze pads were loaded with 500 mg 1-chloro-4-nitrobenzene suspended with 1 or 2 drops of water. The test areas were covered occlusive with a layer of PVC-film (5 x 5 cm) and adhesive tape (Leukoflex). The exposure duration was 24 hours. The reading times were 24, 72 hours and 8 days after application. Day 8 post application was not included in the evaluation. The mean erythema scores at 24, 72 hours and 8 days were 0.0 in all animals in intact skin. The mean oedema score at the 24 hour reading point was 2.17 and at 72 hours 1.0. The criteria for classification are not fulfilled.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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