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Diss Factsheets
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EC number: 215-218-3 | CAS number: 1314-08-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6 Oct 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 luciferase KeratinoSens™ test method)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- preliminary solubility test, not performed according to GLP
- Type of study:
- ARE-Nrf2 luciferase LuSens test method
Test material
- Reference substance name:
- Palladium dihydroxide
- EC Number:
- 235-219-2
- EC Name:
- Palladium dihydroxide
- Cas Number:
- 12135-22-7
- Molecular formula:
- H2O2Pd
- IUPAC Name:
- palladium(2+) dihydroxide
- Details on test material:
- Brown solid, purity 65.3% (as Palladium), stored at room temperature in the dark
Constituent 1
In vitro test system
- Details on the study design:
- Due to the nature of the test item, a preliminary stock suspension/dispersion of the test item in Medium was prepared as follows:
On the day of the experiment, 33.45 mg of the test item were weight in a beaker. The appropriate volume of Medium (1.19 mL) was added into the beaker to formulate the test item.
The Sponsor has advised that DMSO should not be used as the vehicle. - Vehicle / solvent control:
- cell culture medium
Results and discussion
In vitro / in chemico
Results
- Key result
- Group:
- test chemical
- Run / experiment:
- other: solubility trials
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Remarks on result:
- other: Palladium dihydroxide did not produce a visually clear solution or a stable dispersion at sufficient concentrations to meet the OECD Test Guideline for ARE-Nrf2 Luciferase Test Method (LuSens).
Applicant's summary and conclusion
- Interpretation of results:
- other: Palladium dihydroxide did not produce a visually clear solution or a stable dispersion at sufficient concentrations to meet the OECD Test Guideline for ARE-Nrf2 Luciferase Test Method (LuSens).
- Conclusions:
- The test item Palladium dihydroxide formulated in treatment medium is considered unsuitable for the LuSens assay, under the conditions of this study.
- Executive summary:
This study according to OECD442D (non-GLP) was performed to test the solubility of the Palladium dihydroxide and whether the test item is suitable for the ARE-Nrf2 Luciferase Test Method (LuSens).
A stock suspension was prepared in treatment medium. The stock suspension of 200 mM of the test item in treatment medium showed an unstable suspension/dispersion. A further dilution of this stock suspension in treatment medium could not be prepared.
The Sponsor has advised that DMSO should not be used as the vehicle.
Palladium dihydroxide did not produce a visually clear solution or a stable dispersion at sufficient concentrations to meet the OECD Test Guideline for ARE-Nrf2 Luciferase Test Method (LuSens).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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