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Diss Factsheets
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EC number: 215-218-3 | CAS number: 1314-08-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: US CFR guideline study, pre-GLP, with limited reporting.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 974
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 002
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CFR 21, part 191 12 (revised as of April 1, 1973)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- (prior to GLP)
Test material
- Reference substance name:
- Palladium monoxide
- EC Number:
- 215-218-3
- EC Name:
- Palladium monoxide
- Cas Number:
- 1314-08-5
- Molecular formula:
- OPd
- IUPAC Name:
- palladium monoxide
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Palladium (II) oxide
- Substance type: No data
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No.: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Albino rabbits with no known ocular abnormalities.
Test system
- Vehicle:
- not specified
- Controls:
- other: The left eye of each animal served as a control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg (deposited on the eye surface) - Duration of treatment / exposure:
- Presumably the observation period
- Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE: Not removed
SCORING SYSTEM: No data
TOOL USED TO ASSESS SCORE: No data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Number of animals showing irritant reactions
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: Number of animals showing irritant reactions
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: Number of animals showing irritant reactions
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Reversibility:
- other: not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: Number of animals showing irritant reactions
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Reversibility:
- other: Not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: Number of animals showing irritant reactions
- Basis:
- animal #5
- Time point:
- other: 48 hours
- Score:
- 0
- Max. score:
- 6
- Reversibility:
- other: Not applicable
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: Number of animals showing irritant reactions
- Basis:
- animal #6
- Time point:
- other: 72 hours
- Score:
- 0
- Max. score:
- 6
- Reversibility:
- other: Not applicable
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No corrosive conjunctival lesions or severe inflammation of the cornea and anterior chamber of the eyes
- Other effects:
- In one animal, the test material was still present in the conjunctival sac at the end of the observation period, but was completely covered with a thick mucous material.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to an expert review of an unpublished eye irritation study, conducted to US guidelines (CFR 21, part 191 12), a single instillation of palladium monoxide (100 mg) to the eyes of six rabbits produced no signs of irritation.
- Executive summary:
According to an expert review of an unpublished eye irritation study, conducted to US test guidelines (CFR 21, part 191 12), palladium monoxide (100 mg) was instilled into one eye of each of six rabbits. The other eye remained untreated and acted as the control. The treated eye was then assessed for ocular inflammation 24, 48 and 72 hr after application. No reaction was noted in any of the six animals, indicating that the test material was not irritating.
Based on the results of this study, palladium monoxide should not be classified for eye irritation according to EU CLP criteria (EC 1272/2008).
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