Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-203-2 | CAS number: 2386-57-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 19 to October 26, 1995
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- None.
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- The inoculum came from the activated sludge of biological wastewater treatment plant from Abidos (France-64). The effluent, obtained 2 days before seeding the flasks, was centrifuged at approximately 20°C for 20 minutes at 4000 g; the base was resuspended in dilution water in order to keep the concentration unchanged with respect to the sample. The inoculum was preconditioned (aeration) until the flasks were inoculated. The percentage of dry material in the inoculum, determined by desiccation at 105°C until a constant weight is obtained, is 5.62 g/L
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- act. ingr.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Eight flasks were prepared: two inoculum controls for basal oxygen consumption monitoring, two inoculum+test substance, two inoculum+reference substance (sodium benzoate) controls and two toxicity controls (inoculum+test substance+reference substance). The flasks were plugged and installed in the respirometer where the stirring system was started. After a waiting period of 30 min, which was necessary to reach the thermal equilibrium of the solutions at 22°C, the aerated inoculum was added to all flasks, so that final inoculum concentration was 29.9 mg/L suspended solid. The flasks were incubated for 28 days.
- Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- None.
- Test performance:
- Sodium benzoate reached 86% biodegradation (i.e. more than the 60% validity criterion) within 14 days and the toxicity control reached 92% within 14 days (i.e. more than the 25% criterion below which it is considered that the test substance is toxic to the inoculum).
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 90
- Sampling time:
- 28 d
- Details on results:
- The maximum biodegradation level of methanesulfonate acid was 90% after 28 days. 11 days were needed to reach 10% biodegradation and 84% biodegradation were observed within 10 further days. Therefore, the test substance was biodegraded by more than 60% during this ten-day window and by more than 70% at the end of the test. The substance is considered readily biodegradable.
- Results with reference substance:
- Sodium benzoate reached 86% biodegradation within 14 days (i.e. more than the 60% after 28 days validity criterion set out in the OECD 301F guideline) .
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Methane sulfonate is readily biodegradable.
- Executive summary:
The purpose of this study was to assess the ready biodegradability of the test item according to the OECD 301F guideline. According to this guideline, the pass level for ready biodegradability is 60% of ThOD. The level has to be reached in a 10 -day window which begin after biodegradation of the test item has reached 10%. The pass level must be observed within the 28 -day period of the study. Under the test conditions, ultimate biodegradation of methanesulfonate was 90% after 28 days. At the end of the 10 -day window, ultimate biodegradation was 84%. All validity criteria set out in the OECD 301F guideline were fulfilled. Therefore, the study showed that methanesulfonate must be considered readily biodegradable.
Reference
Description of key information
A read-across was done for sodium methanesulphonate from methanesulphonic acid (see read-across justification).
The purpose of this study was to assess the ready biodegradability of the test item according to the OECD 301F guideline. According to this guideline, the pass level for ready biodegradability is 60% of ThOD. The level has to be reached in a 10 -day window which begin after biodegradation of the test item has reached 10%. The pass level must be observed within the 28 -day period of the study. Under the test conditions, ultimate biodegradation of methanesulfonate was 90% after 28 days. At the end of the 10 -day window, ultimate biodegradation was 84%. All validity criteria set out in the OECD 301F guideline were fulfilled. Therefore, the study showed that methanesulfonate must be considered readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.