Registration Dossier
Registration Dossier
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EC number: 257-399-1 | CAS number: 51765-51-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from handbook .
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Heterocyclic and Miscellaneous Nitrogen Compounds. pp. 2719-2727
- Author:
- Reinhardt, C.F
- Year:
- 1 981
- Bibliographic source:
- Patty's Industrial Hygiene and Toxicology, 3rd revised edition, Clayton, G.D. And F.E. Clayton, eds. J. Wiley & Sons, New York, NY U.S., 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Skin sensitizing potential of Pyridine was evaluated in guinea pig.
- GLP compliance:
- not specified
- Type of study:
- other: No data available.
- Justification for non-LLNA method:
- Not specified.
Test material
- Reference substance name:
- Pyridine
- Cas Number:
- 110-86-1
- Molecular formula:
- C5H5N
- IUPAC Name:
- Pyridine
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Pyridine
- Molecular formula: C5H5N
- Molecular weight: 79.1g/mol
- Substance type:Organic
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available.
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: No data available.
Challenge
- Route:
- other: No data available.
- No. of animals per dose:
- No data available.
- Details on study design:
- No data available.
- Challenge controls:
- No data available.
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- Not sensitizing
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
No sensitization reaction observed
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- Skin sensitizing potential of Pyridine was evaluated in Guinea pig . According to the text Pyridine was considered to be non sensitizing in Guinea pig.
- Executive summary:
Skin sensitizing potential of Pyridine (110 -86 -1)was evaluated inGuinea pig. According to the text Pyridine(110 -86 -1) was considered to be non sensitizing in Guinea pig.
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