N-(2-phenoxyphenyl)methanesulphonamide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from Authoritative database

Data source

Reference

Reference Type:

review article or handbook

Title:

Acute oral toxicity study of 3-Cyanopyridine in rats

Author:

J-CHECK

Year:

2010

Bibliographic source:

Ministry of Health, Labour and Welfare", "Ministry of the Environment" and "National Institute of Technology and Evaluation, J-CHECK , 2010

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Acute oral toxicity study of 3-Cyanopyridine in rats

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Nicotinonitrile

Cas Number:

100-54-9

Molecular formula:

C6H4N2

IUPAC Name:

Nicotinonitrile

Details on test material:

- Name of test material (as cited in study report): 3-Cyanopyridine
- Molecular formula (if other than submission substance): C6H4N2
- Molecular weight (if other than submission substance): 104.12 g/mole
- Substance type: Organic

Specific details on test material used for the study:

- Name of test material (as cited in study report): 3-Cyanopyridine
- Molecular formula (if other than submission substance): C6H4N2
- Molecular weight (if other than submission substance): 104.12 g/mole
- Substance type: Organic
Purity 99.9%
- Impurities (identity and concentrations): 0.1 %

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male/female

Details on test animals or test system and environmental conditions:

Males\ females
No data available

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Remarks:

for injection

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 0, 1297, 1388, 1485, 1589, 1700 mg/kg/day
- Amount of vehicle (if gavage): No data available
- Justification for choice of vehicle: Water for injection

Doses:

0, 1297, 1388, 1485, 1589, 1700 mg/kg/day

No. of animals per sex per dose:

Total : 60
0 mg/kg/day: 5 male, 5 Female
1297 mg/kg/day: 5 male, 5 Female
1388 mg/kg/day: 5 male, 5 Female
1485 mg/kg/day: 5 male, 5 Female
1589 mg/kg/day: 5 male, 5 Female
1700 mg/kg/day: 5 male, 5 Female

Control animals:

no

Details on study design:

- Necropsy of survivors performed: yes
- Other examinations performed: Mortality, clinical signs, body weight and gross pathology were examined.

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD0

Effect level:

1 475 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality observed

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

1 455 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality observed

Mortality:

Deaths occurred in 1297 mg/kg and more groups for males and in 1388 mg/kg and more groups for females.

Clinical signs:

other: Hypoactivity, bradypnea, salivation, lacrimation and wheezing were observed in both male and female rats treated with 1297 mg/kg or more on the day of administration.

Gross pathology:

Pathological lesions were observed in the stomach, lung, liver, urinary bladder and testis of treated rats.

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

LD50 was considered to be 1475mg/kg bw for male and 1455 mg/kg bw for female when Crj:CD (SD) male and female rats were treated with 3-Cyanopyridine orally by gavage.

Executive summary:

In a acute oral toxicity study,Crj:CD (SD) male and female ratswere treated with3-Cyanopyridine in the concentration of0, 1297, 1388, 1485, 1589, 1700 mg/kg/dayorally by gavageinWater for injection. Deaths occurred in 1297 mg/kg and more groups for males and in 1388 mg/kg and more groups for females. Hypoactivity, bradypnea, salivation, lacrimation and wheezing were observed in both male and female rats treated with 1297 mg/kg or more on the day of administration. Decrease in body weights was in observed both male and female rats treated with 1297 mg/kg or more on the day after administration. In addition, Pathological lesions were observed in the stomach, lung, liver, urinary bladder and testis of treated rats. Therefore,LD50 was considered to be 1475mg/kg bw for male and 1455mg/kg bwfor female whenCrj:CD (SD) male and female ratswere treated with3-Cyanopyridine orally by gavage.