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EC number: 200-081-4 | CAS number: 51-17-2
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental results of read across chemicals
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Refer principle below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as- 1. and 2.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):Benzimidazole
- Molecular formula : C7H6N2
- Molecular weight: 118.1384 g/mol
-Smilies notation: c12c(nc[nH]1)cccc2
- Inchi: 1S/C7H6N2/c1-2-4-7-6(3-1)8-5-9-7/h1-5H,(H,8,9)
- Substance type: Organic
- Physical state: Solid - Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Details on test conditions:
- 1. no data
2. TEST MEDIUM
- Volume used/treatment: Water was 18 MΩ prepared using nanopure device - pH:
- 8
- Temp.:
- 10 °C
- Initial conc. measured:
- 50 mg/L
- Remarks:
- other details not available
- Transformation products:
- not specified
- Temp.:
- 55 °C
- DT50:
- >= 29 - <= 146 d
- Type:
- not specified
- Remarks on result:
- other: at pH range 4-9
- pH:
- 8
- Temp.:
- 10 °C
- DT50:
- 1.8 yr
- Type:
- not specified
- Remarks on result:
- other: other details not available
- pH:
- 7
- Temp.:
- 90 °C
- Hydrolysis rate constant:
- 0.32 h-1
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: at 0.2 M, 0.1 M and 0.05 M buffer solution
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the structurally and functionally similar read across chemicals and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be in range 29-146 days at pH 5-9 and 1.8 years at pH 8.
Based on the range half-life value, it is concluded that test substance Benzimidazole (CAS no. 51-17-2) not hydrolysable - Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical Benzimidazole (CAS no. 51-17-2).The studies are as mentioned below:
The first study was experimental study reviewed from authoritative database (HSDB) in this study the half life of hydrolysis of test chemical was determined to be in range of 29-146 day at range pH 5-9 and temperature 55oC. On the basis of this half life value it is concluded that test chemical shows negligible hydrolysis.
Next experimental study was reviewed from Water Research journal in this study the test chemical showed half life of 1.8 years at pH 8 and at temperature 10 degree C. On the basis of this half life value it can be concluded that test chemical is not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemicals and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be in range 29-146 days at pH 5-9 and 1.8 years at pH 8.
Based on the range half-life value, it is concluded that test substance Benzimidazole (CAS no. 51-17-2) not hydrolysable.
Reference
Description of key information
On the basis of the experimental studies of the structurally and functionally similar read across chemicals and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be in range 29-146 days at pH 5-9 and 1.8 years at pH 8.
Based on the range half-life value, it is concluded that test substance Benzimidazole (CAS no. 51-17-2) not hydrolysable
Key value for chemical safety assessment
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical Benzimidazole (CAS no. 51-17-2).The studies are as mentioned below:
The first study was experimental study reviewed from authoritative database (HSDB) in this study the half life of hydrolysis of test chemical was determined to be in range of 29-146 day at range pH 5-9 and temperature 55oC. On the basis of this half life value it is concluded that test chemical shows negligible hydrolysis.
Next experimental study was reviewed from Water Research journal in this study the test chemical showed half life of 1.8 years at pH 8 and at temperature 10 degree C. On the basis of this half life value it can be concluded that test chemical is not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemicals and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be in range 29-146 days at pH 5-9 and 1.8 years at pH 8.
Based on the range half-life value, it is concluded that test substance Benzimidazole (CAS no. 51-17-2) not hydrolysable.
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