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EC number: 200-081-4 | CAS number: 51-17-2
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- Data is from authorative database
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Environmental Bioconcentration of test substance 1H-benzimidazole was determine using log Kow of 1.32 and a regression derived equation.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- -IUPAC name: 1H-benzimidazole
- Name of test material (as cited in study report):Benzimidazole
- Molecular formula: C7H6N2
- Molecular weight: 118.1384 g/mol
- Substance type: Organic
- Physical state: Solid - Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: aquatic organisms
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- natural water: freshwater
- Hardness:
- No data
- Test temperature:
- No data
- pH:
- No data
- Dissolved oxygen:
- No data
- TOC:
- No data
- Salinity:
- No data
- Conductivity:
- No data
- Details on test conditions:
- No data
- Nominal and measured concentrations:
- No data
- Reference substance (positive control):
- not specified
- Key result
- Type:
- BCF
- Value:
- 2.1 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- other: regression derived equation
- Validity criteria fulfilled:
- not specified
- Conclusions:
- From authorative database HSDB, an estimated BCF of 2.1 (dimensionless) was calculated for 1H-benzimidazole (i.e benzimidazol),using log Kow of 1.32 and a regression derived equation.
- Executive summary:
Based on an experimental log/octanol water partition coefficient of 1.32, a bioconcentration factor of 2.1 (dimensionless)can be calculated for 1H-benzimidazole (i.e benzimidazol) using an regression derived equation. This BCF suggests the potential of target chemical (Cas no.51 -17 -2) for bioconcentration in aquatic organisms is low.
Reference
Description of key information
Based on an experimental log/octanol water partition coefficient of 1.32, a bioconcentration factor of 2.1 dimensionless can be calculated for 1H-benzimidazole (i.e benzimidazol) using an regression derived equation. This BCF suggests the potential of target chemical (CAS no.51 -17 -2) for bioconcentration in aquatic organisms is low.
Key value for chemical safety assessment
- BCF (aquatic species):
- 2.1 dimensionless
Additional information
Four different studies which includes one experimental from authoritative database and remaining three from validated predicted databases for bioaccumulation endpoint of target chemical 1H-benzimidazole (CAS no. 51-17-2) are summarized as followed:
First study from experimental result from authoritative database (HSDB by US EPA; 2017) suggest the bio concentration factor (BCF) for 1H-benzimidazole is 2.1 (dimensionless) based on an experimental log/octanol water partition coefficient of 1.32 and using an regression derived equation. This BCF indicate the potential of target chemical (CAS no.51 -17 -2) for bioconcentration in aquatic organisms is low.
Above experimental result is supported by prediction report by BCFBAF (v3.00) model which indicate the estimated bio concentration factor (BCF) for 1H-benzimidazole is 3.451 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that 1H-benzimidazole is not expected to bio accumulate in the food chain.
Another predicted database, PBT profiler propose the Bioaccumulation factor (BCF) was predicted to be 3.4 L/kg wet-wt at 25 deg.C for test chemical 1H-benzimidazole.
Further, Scifinder database indicates the Bioconcentration factor (BCF) for target chemical 1H-benzimidazole to be 1.0 at pH 1-4; 1.29 at pH 5; 4.35 at pH 6; 5.72 at pH 7; 5.91 at pH 8;5.93 at pH 9 and 5.92 at pH 10 and temperature 25 deg.C. Based on the BCF concentration at all pH range i.e 1 -10 it is concluded that the test chemical 1H-benzimidazole is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.
All predicted and experimental values for bioaccumulation is in the range of 1.0 -5.93 (L/kg or dimensionless) conclude the target chemical 1H-benzimidazole (CAS no. 51-17-2) is non bioaccumulative in aquatic environment as it does not exceed the BCF criteria of 2000.
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