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EC number: 255-138-6 | CAS number: 40910-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed equivalent to OECD 404 guideline. Non GLP. Observation period was limited to directly and 48 hours after patch removal.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Observation period was limited to directly and 48 hours after patch removal. Limited details on animals and environmental conditions.
- GLP compliance:
- no
- Remarks:
- not present at the time of performance.
Test material
- Reference substance name:
- 3-(1-ethoxyethoxy)-3,7-dimethylocta-1,6-diene
- EC Number:
- 255-138-6
- EC Name:
- 3-(1-ethoxyethoxy)-3,7-dimethylocta-1,6-diene
- Cas Number:
- 40910-49-4
- Molecular formula:
- C14H26O2
- IUPAC Name:
- 1-[(3,7-dimethylocta-1,6-dien-3-yl)oxy]-1-ethoxyethane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Elintaal F
- Description: Clear colourless liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Adult animals
ENVIRONMENTAL CONDITIONS
No data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 12
- Details on study design:
- STUDY DESIGN
The test substance is brought on the intact or abraded skin under a surgical patch measuring 2.54 x 2.54 cm.
TEST SITE
Twenty four hours prior to applying the material, the hair is removed from the back of the animal with an electric clipper in such a way as to avoid abrasions.
Six rabbits are treated on the intact skin, the other on the abraded skin. The abrasions are minor incisions through the stratum corneum, but not sufficiently deep to disturb the derma or to produce bleeding.
REMOVAL OF TEST SUBSTANCE
Twenty four hours after the application, the dressing was removed.
The skin reactions were assessed directly (first reading) and 48 hours (second reading) after the removal of the dressings and test substance.
SCORING SYSTEM:
The irritation at the first reading was assessed according to the numerical scoring system according to OECD 404.
The second reading is carried out on the basis of the CIVO-grading system:
0 = no reaction at all
1 = very slight scaliness
2 = distinct scaliness or very slight incrustation
3 = distinct incrustation
4 = secere incrustation
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: erythema, edema and scaliness
- Basis:
- mean
- Remarks:
- animal #1, #2, #3, #4 and #6
- Time point:
- other: 48 hours
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: score intact skin
- Irritation parameter:
- other: erythema, edema and scaliness
- Basis:
- animal #5
- Time point:
- other: 48 hours
- Score:
- 1
- Max. score:
- 4
- Remarks on result:
- other: score intact skin
- Irritation parameter:
- other: erythema, edema and scaliness
- Basis:
- mean
- Remarks:
- animal #7, #8, #9, #10, #11 and #12
- Time point:
- other: 48 hours
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: score abraded skin
- Irritant / corrosive response data:
- Elintaal F caused moderate skin irritation. Its dermal effects consisted of very slight or well-defined erythema, very slight ischemia, slight or distinct scaliness and very slight or slight edema.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- In a skin irritation study with rabbits, performed equivalent to OECD 404 test guideline, irritation was observed.
- Executive summary:
Elintaal F was tested in a skin irritation study with rabbits, performed equivalent to OECD 404 test guideline.
Elintaal F caused moderate skin irritation 48 hours after patch removal. Its dermal effects consisted of very slight or well-defined erythema, very slight ischemia, slight or distinct scaliness and very slight or slight edema.
As the observation period was limited to 48 hours after patch removal and no reversibility has been observed, Elintaal F should be classified as skin irritation cat.2 and should be labelled with H315: Causes skin irritation according to Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures.
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