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EC number: 255-138-6 | CAS number: 40910-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 July, 1980 - 04 August, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well described short report. Dose, number of animals (with details), experimental design and observation period are described in the study. Performed in compliance with the FDA's GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Elintaal
- Description: Clear liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Perfection breeders
- Age at study initiation: approx. 9 weeks old
- Weight at study initiation: 2.1 - 2.5 kg
- Housing: Two animals per cage were housed in suspended wire mesh cages.
- Diet: Fresh Purina rabbit chow was freely available
- Water: Water was freely available
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): temperature controlled
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Immediately prior to dosing, the fur was clipped from the abdomen of the animals.
- Area of exposure: 200 square cm
- % coverage: approx. 10% of the body surface
- Abrasions were made in 1/2 of the rabbits. The abrasions, extending the length of the exposure site, scratched the stratum corneum but did not reach the derma or produce bleeding.
- The patches were secured with adhesive tape and the trunks were wrapped with impervious material.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no, exposure site was wiped to remove excess material.
TEST MATERIAL
- Amount applied: the dose was based on the sample weight as calculated from the specific gravity. - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Dermal reactions were scored at 1, 7 and 14 days after removal of the patches.
The animals were observed daily for 14 days for signs of toxicity, clinical signs and mortality.
Body weights were recorded pretest and in the survivors at 14 days.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: Diarrhea and yellow nasal discharge was observed (in 2 animals).
- Gross pathology:
- No abnormalities were observed.
- Other findings:
- Erythema was observed, slight/well defined on days 1 and 7, generally cleared by day 14.
Edema was observed, absent to severe on day 1, completely cleared on day 14.
Treated skin was found damaged in 2 animals at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal toxicity with male rabbits, an LD50 >5000 mg/kg bw was determined.
- Executive summary:
Elintaal was tested in an acute dermal toxicity study with male rabbits at 5000 mg/kg body weight. The study was performed equivalent to OECD 402 guideline and GLP principles. No deaths occurred. Diarrhea and yellow nasal discharge was observed.
Erythema was observed, slight/well defined on days 1 and 7, generally cleared by day 14. Edema was observed, absent to severe on day 1, completely cleared on day 14. Treated skin was found damaged in 2 animals at necropsy. Based on the results, an LD50 >5000 mg/kg bodyweight was determined.
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