Registration Dossier
Registration Dossier
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EC number: 268-667-2 | CAS number: 68133-24-4
Endpoint summary
Administrative data
Description of key information
Six rabbits were exposed dermally (under occlusion) to 0.5 g of the similar substance 1 for 24 hours. Very limited oedema and erythema were reported at the 24 h examination. These effects were fully reversible after 72 hours. The substance is not irritating to the skin (Ciba 1974).
A study similar to OECD 405 was performed on similar substance 1. The substance was installed in the conjuntival sac of the eye of 6 rabbits. The eyes of 3 of these were washed after 30 seconds. Observations for irritancy were done at 1, 6, 24, 48 and 72 hours after installation. No irritant effects became apparent except for slight cornea effects and slight redness that were fully reversible after 72 hours. There was no difference between animals with washed eyes and animals that were not washed. Therefore it is concluded that the substance is not irritating to the eyes (Ciba 1974)
Read across is dicussed in section 13
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the available data the substance does not need to be classified for skin and eye irritation according to Regulation ((EC) No 1272/2008 (CLP)
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