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EC number: 211-838-3 | CAS number: 700-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,3,5-trimethylhydroquinone
- EC Number:
- 211-838-3
- EC Name:
- 2,3,5-trimethylhydroquinone
- Cas Number:
- 700-13-0
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 2,3,5-trimethylbenzene-1,4-diol
- Details on test material:
- - Name of test material (as cited in study report): 2,3,6-trimethylhydroquinone
- Batch: Feb. 20, 1990
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: GAUKLER; D-6050 OFFENBACH/MAIN, Germany
- Weight at study initiation: mean 2.86 kg (male), 2.61 kg (female)
- Housing: stainless stell cages with wire mesh floor (area 40 cm x 51 cm)
- Diet (e.g. ad libitum): 4 MM; FIRMA KLINGENTALMUEHLE AG, CH-4303 KAISERAUGST, SWITZERLAND (ABOUT 130 G PER ANIMAL PER DAY)
- Water (e.g. ad libitum): ABOUT 250 ML TAP WATER PER ANIMAL PER DAY
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated other eye of same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml (ca. 12 mg) - Duration of treatment / exposure:
- single application without washing
- Observation period (in vivo):
- 21 d
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
SCORING SYSTEM:
Cornea Opacity-degree of density (area most dense taken for reading)
0 = No opacity
1 = Scattered or diffuse area, details of iris clearly visible
2 = Easily discernible translucent areas, details of iris slightly obscured
3 = Opalescent areas, no details of iris visible, size of pupil barely discernible
4 = Opaque, iris invisible
Area of cornea involved
1 = One quarter (or less) but not zero
2 = Greater than one quarter, but less than half
3 = Greater than half, but less than three quarters
4 = Greater than three quarters, up to whole area
Iris
0 = Normal
1 = Folds above normal, congestion, swelling, circumcorneal injection (any or all of these or combination af any thereof) iris still reacting to light (sluggish reactions is positive)
2 = No reaction to light, hemorrhage, gross destruction (any or all of these)
Conjunctivae
Redness (refers to palpebral and bulbar conjunctivae excluding cornea and iris)
0 = Vessels normal
1 = Vessels definitely injected above normal
2 = More diffuse, deeper crimson red, individual vessels not easily discernible
3 = Diffuse beefy red
Chemosis
0 = No swelling
1 = Any swelling above normal (includes nictitatinq membrane)
2 = Obvious swelling with partial eversion of lids
3 = Swelling with lids about half closed
4 = Swelling with lids about half closed to completely closed
Discharge
0 = No discharge
1 = Any amount different from normal (does not include small amounts observed in inner canthus of normal animals
2 = Discharge with moistening of the lids and hairs just adjacent to lids
3 = Discharge with moistening of the lids and hairs, and considerable area around the eye
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- other: Study discontinued after 8 days for 2/3 animals
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable
- Remarks on result:
- other: Study discontinued after 8 days for 2/3 animals
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 2.6
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 d
- Remarks on result:
- other: Study discontinued after 8 days for 2/3 animals
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 3.2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 15 d
- Remarks on result:
- other: Study discontinued after 8 days for 2/3 animals
Any other information on results incl. tables
Animal 1: male, 2.94 kg
Animal 2: female, 2.61 kg
Animal 3: male, 2.77 kg
Table: Individual irritation findings (Draize scores) at the different
reading times
Readings | Animal | cornea | Iris | conjunctiva | Symptons | |||
opacity | area | redness | swelling | discharge | ||||
1 h | 1 | 0* | 0* | 0* | 2* | 4 | 2 | |
2 | 0 | 0 | 0 | 2 | 3 | 2 | ||
3 | 0* | 0* | 0 | 2 | 4 | 3 | ||
24 h | 1 | 1 | 4 | 0 | 3 | 3 | 2 | pc,c |
2 | 1* | 4* | 0* | 2 | 3 | 2 | db,s | |
3 | 1* | 4* | 0* | 2 | 4 | 2 | db,s | |
48 h | 1 | 1 | 4 | 0 | 3 | 3 | 1 | pc,s,re |
2 | 1* | 4* | 0* | 2 | 3 | 3 | db,s | |
3 | 1* | 4* | 0* | 2 | 4 | 3 | db,s | |
72 h | 1 | 1 | 4 | 0 | 3 | 2 | 1 | pc,s,re |
2 | 1* | 4* | 0* | 3 | 3 | 3 | s | |
3 | 1* | 4* | 0* | 3 | 4 | 3 | db,s | |
8 d | 1 | 2 | 2 | 0 | 2 | 1 | 1 | pc,s,re,mv,lh,lc |
2 | 2* | 2* | 0* | 2 | 2 | 3 | s,re,st | |
3 | 2* | 2* | 0* | 2 | 3 | 2 | s,re.lh | |
15 d | 1 | 1 | 1 | 0 | 2 | 0 | 0 | pc,re,mv,lh,lc |
2 | study discontinued | |||||||
3 | study discontinued | |||||||
21 d | 1 | 1 | 1 | 0 | 1 | 0 | 0 | pc,re,mv,lh,lc |
2 | ||||||||
3 | ||||||||
mean 24 - 72 h | 1 | 1.0 | 0.0 | 3.0 | 2.7 | |||
2 | 1.0 | 0.0 | 2.3 | 3.0 | ||||
3 | 1.0 | 0.0 | 2.3 | 4.0 | ||||
mean | 1.0 | 0.0 | 2.6 | 3.2 |
*: score could not be read due to severe edema or suppuration
The study was discontinued for animals no 2 and 3 by study day 8 due to
severe irritation.
Abbreviations:
db = discharge of blood
lh = loss of hair at the margins of the eyelids
lc = loss of corneal tissue
mv = marginal vascularization of the cornea
pc = pupil contracted
re = small retractions in the eyelids
s = suppuration
st = staphyloma
Applicant's summary and conclusion
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