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Diss Factsheets
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EC number: 211-838-3 | CAS number: 700-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Internal BASF method was used which was in large part equivalent to OECD guideline 403
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,3,5-trimethylhydroquinone
- EC Number:
- 211-838-3
- EC Name:
- 2,3,5-trimethylhydroquinone
- Cas Number:
- 700-13-0
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 2,3,5-trimethylbenzene-1,4-diol
- Details on test material:
- - Name of test material (as cited in study report): 2,3,5-trimethylhydroquinone
- Substance No.: 77/749
- Substance type: yellow powder
- Analytical purity: 99.5%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: MUS RATTUS, Brunnthal, Germany
- Weight at study initiation: mean 185 g (male), 183 g (female)
- Diet (e.g. ad libitum): Herilan MRH, H . EGGERSMANN KG, Rinteln/Weser, Germany, ad libitum
- Water (e.g. ad libitum): drinking water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 50 - 60
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: ethanol / Lutrol E 400 (1:1)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: Zweistoffdüse (Rhema ), Infu 362 Infusionspumpe (Datex)
- Temperature, humidity, pressure in air chamber: ca. 1.5 Pa
TEST ATMOSPHERE
- Brief description of analytical method used: gas chromatography in DMF; sample was taken with 2 connected Impinger bottles. Amount was up to 30 l with 3 l/min
- Samples taken from breathing zone: yes
VEHICLE
- Composition of vehicle (if applicable): Ethanol p.a. and Lutrol E 400 1:1 - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gas chromatography
- Duration of exposure:
- 4 h
- Concentrations:
Group 5,4,3,2,1:
analytical concentration: 0.64, 0.87, 1.38, 1.73, 1.96 mg/l
nominal concentration: 1.70, 2.48, 6.26, 9.17, 9.17 mg/l- No. of animals per sex per dose:
- 20
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: prior to study; days 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology - Statistics:
- Probit analysis according to D .J . Finney (Probitanalysis 1971, Seite 1 - 150). Published by the Syndics of the Cambridge University Press, Bentley House, 200 Euston Road, London
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 1.5 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: aerosol
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 1.2 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: aerosol
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 1.7 mg/L air
- Exp. duration:
- 4 h
- Remarks on result:
- other: aerosol
- Mortality:
- 1.96 mg/l: 9/10 males; 8/10 females
1.73 mg/l: 8/10 males, 6/10 females
1.38 mg/l: 8/10 males, 1/10 females
0.87 mg/l: 1/10 males, 0/10 females
0.64 mg/l: 0/10 males, 0/10 females
Deaths occurred within 2 days after dosing - Clinical signs:
- other: 1.38, 1.73, 1.96 mg/l: attempts to escape, eyelid closure, secretion out of eyes and nose, dyspnea, reduced pain reflex, squatting posture, spastic gait, corneal opacity, swollen snout, ruffled fur with substance adhesions. 0.87 mg/l: attempts to escap
- Body weight:
- Body weight gain was clearly retarded in males of groups 2 and 3 and in females of group 1 at 7 days after exposure. Animals had gained weight at 14 days; however, only body weights of the group-1 females had become similar to control values. Slight retardation of body weight gain was also seen for males of the groups 1 and 4. Body weight gain of males and females of the groups 2, 3, 4, and 5 were not significantly different from control
- Gross pathology:
- changes of the heart (acute vestibular dilatation, acute congestive hyperemia) and lungs (slight to moderate pulmonary emphysema) in decedents; no pathological findings in survivors.
Any other information on results incl. tables
Body weight:
dose | mean body weight (g) | ||||||
prior to study | day 7 | day 14 | |||||
mg/l | male | female | male | female | male | female | Group |
1.96 | 187 | 185 | 220 | 185 | 258 | 211 | 1 |
1.73 | 192 | 182 | 201 | 199 | 250 | 215 | 2 |
1.38 | 175 | 185 | 188 | 202 | 246 | 222 | 3 |
0.87 | 178 | 178 | 212 | 198 | 256 | 217 | 4 |
0.64 | 185 | 183 | 229 | 202 | 279 | 220 | 5 |
0 | 191 | 185 | 235 | 204 | 279 | 215 | control |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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