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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1959
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Percutane Resorption von aetherischen Oelen und ihren Inhaltsstoffen
Author:
Meyer
Year:
1959
Bibliographic source:
Arzneimittelforschung 9, 516-519, 1959

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The absorption velocity of the test substance was estimated by applying the test item together with 0.25% eserin (test substance functions as vehicle) to 2.2 cm2 shaved abdominal skin of mice for 2 hours. Eserin is used as an indicator of resporption because of its measurable effects on the striated muscles. The lag time between the application till the observable periodical irritation of the jaw muscles is taken as a measure of the absorption velocity of the test item.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzyl cinnamate
EC Number:
203-109-3
EC Name:
Benzyl cinnamate
Cas Number:
103-41-3
Molecular formula:
C16H14O2
IUPAC Name:
benzyl 3-phenylacrylate

Test animals

Species:
mouse
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
none available

Administration / exposure

Type of coverage:
open
Vehicle:
unchanged (no vehicle)
Duration of exposure:
2 h
Doses:
not specified
No. of animals per group:
not specified. According to the authors 5 tests were evaluated, it is not verifiable if this corresponds to 5 animals
Control animals:
no

Results and discussion

Signs and symptoms of toxicity:
no effects
Dermal irritation:
not specified

Any other information on results incl. tables

No effects of eserin were observed. Hence, the test substance - which is used as a vehicle - is not taken up systemically when applied to mice skin.

Applicant's summary and conclusion

Conclusions:
The test substance was not found to be resorbed in a measurable quantity in this test system
Executive summary:

The absorption velocity of the test substance was estimated by applying the test item together with 0.25% eserin (test substance functions as vehicle) to 2.2 cm2 shaved abdominal skin of mice for 2 hours. Eserin is used as an indicator of resorption because of its measurable effects on the striated muscles. The lag time between the application till the observable periodical irritation of the jaw muscles is taken as a measure of the absorption velocity of the test item.

The test substance was not found to be resorbed in a measurable quantity in this test system.