Registration Dossier
Registration Dossier
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EC number: 211-536-1 | CAS number: 659-70-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Isoamyl isovalerate is a small aliphatic ester with a molecular weight of 172.3 g/mole. It has limited water solubility (48 mg/L) with a partition coefficient (Log Pow) of 3.8 at pH 7.4 and a vapor pressure of 1.3 hPa at 20°C. With these physical/chemical (phys/chem) properties, oral, dermal and inhalation exposures are all potential routes of exposure.
1. The test item can be assumed to be absorbed by the oral, dermal, and inhalation routes of exposure, however default absorption values are used in the derivation of DNELs, according to REACH guidance R.8 page 19
2. The test item is rapidly and completely hydrolyzed to form isoamyl alcohol and isovalerate.
3. Both isoamyl alcohol and isovalerate are readily incorporated into intermediary metabolism.
4. There is no evidence of the formation of reactive or toxic metabolites from either isoamyl alcohol or isovalerate.
5. The test item is unlikely to bioaccumulate because of its extensive metabolism and rapid excretion.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
