2,6-dimethylmorpholine

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Principles of method if other than guideline:

Internal test method, see details in "Any other information on materials and methods incl. tables"

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,6-dimethylmorpholine

EC Number:

205-509-3

EC Name:

2,6-dimethylmorpholine

Cas Number:

141-91-3

Molecular formula:

C6H13NO

IUPAC Name:

2,6-dimethylmorpholine

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: ca. 50 cm2

REMOVAL OF TEST SUBSTANCE
- Washing (if done): water/Lutrol (1:1)
- Time after start of exposure: 24 h

Duration of exposure:

14 days

Doses:

1000, 2000 mg/kg bw

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: several times on the day of application and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 1 000 - < 2 000 mg/kg bw

Mortality:

see details in table in remarks on results.

Clinical signs:

other:

Body weight:

other body weight observations

Remarks:

no data

Gross pathology:

Animals that died:
Heart: acute dilatation of the ventricle acute congestion;
Stomach: bloody ulcerations;
Liver: grey-colored lobular periphery;

Any other information on results incl. tables

Mortality:

Dose mg/kg	Conc. %	Animal	1 h	24 h	48 h	7 days	14 days
2000	100	3 m 3 f	0/3 0/3	2/3 3/3	3/3 3/3	3/3 3/3	3/3 3/3
1000	100	3 m 3 f	0/3 0/3	0/3 0/3	0/3 1/3	0/3 1/3	0/3 1/3

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria