Registration Dossier
Registration Dossier
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EC number: 205-509-3 | CAS number: 141-91-3
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Method not validated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Initiation of hepatocarcinogenesis by endogenously formed N-nitrosobis(2-hydroxypropyl)amine, N-nitrosodiethanolamine and N-nitroso-2,6-dimethylmorpholine in rats
- Author:
- Yamamoto K et al.
- Year:
- 1 995
- Bibliographic source:
- Carcinogenesis 16 (11): 2633-2636.
Materials and methods
- Type of study / information:
- liver foci test
- Principles of method if other than guideline:
- see details in "Any other information on materials and methods incl. tables"
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,6-dimethylmorpholine
- EC Number:
- 205-509-3
- EC Name:
- 2,6-dimethylmorpholine
- Cas Number:
- 141-91-3
- Molecular formula:
- C6H13NO
- IUPAC Name:
- 2,6-dimethylmorpholine
Constituent 1
Results and discussion
Any other information on results incl. tables
| Treatment | No. of rats | No of foci (per cm2) | No of foci (per cm3) | percent of area occupied by foci (%) | ||
| 0.25% test substance | 8 | 1±1 | 11±9 | 0.2±0.2 | ||
| 0.25% test substance + 0.3% NaNO2 | 10 | 32±8 | 389±106 | 14.7±9.2 |
Applicant's summary and conclusion
- Conclusions:
- Number of foci per cm² were significantly increased in the group given the test substance together with nitrite compared to values for groups given test article or nitrite alone. Further, the numbers of lesions were essentially similar to those found in rats given carcinogenic doses of Nitroso-dimethylmorpholine. The results clearly demonstrate hepatocyte initiation activities of endogenously formed carcinogens.
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