Registration Dossier
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EC number: 203-751-4 | CAS number: 110-27-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
In general, all EC50(48h) values in the category, derived with different invertebrate species for various test substances that belong to the category have been found above the limit of water solubility, so that no direct toxicity of dissolved substance was found (chemical toxicity). There were, however, several descriptions of indirect toxicity by physical effects of the test substance at concentrations between 1 and 100 mg/L.
In the selected key study with Daphnia magna, three different treatments of Isopropyl Myristate were applied for the test performance according to EU Method C.2 under GLP conditions (Küch 1995). Method 1: limit test 100 mg/L test substance and 5 min ultrasonic treatment; Method 2: limit test 100 mg/L, 24 h stirring and removal of undissolved test substance via filtration through glass fibre filter; Method 3: 3-5 times saturation, 24 h stirring. In all tests animals were swimming at the water surface. Furthermore, using method 1, an oily film was present. Method 1 (limit test without substance separation) resulted in an EC50 < 100 mg/L (nominal), whereas in method 2 and 3 (both tests with substance separation) the EC50 was established as greater than the water solubility. In conclusion: the results indicate that physical effects may occur in the prescence of undissolved test material.
In a supporting study, the acute toxicity of Isopropyl myristate to Daphnia magna was tested under static freshwater conditions according to OECD 202 (Kirch 1993), resulting in an EC50(48h) value of 100 mg/L. Since a suspension was tested, the effects could be attributed to physical effects.
In further read-across from Isopropyl oleate (CAS 112-11-8), the acute toxicity to the marine species Crangon crangon was tested under constant stirring (Clitherow 1991).Part of the test sample was observed to remain on the liquid surface, even with continuous stirring. The agitation was sufficient to maintain a distribution within the body of the liquid, but at higher concentrations the thickness of the floating layer increased. No mortalities occured up the highest concentration tested, 8500 mg/L.
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